ID F6YZ64_HORSE Unreviewed; 385 AA.
AC F6YZ64;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=WD repeat domain 74 {ECO:0000313|Ensembl:ENSECAP00000007186.2};
GN Name=WDR74 {ECO:0000313|Ensembl:ENSECAP00000007186.2,
GN ECO:0000313|VGNC:VGNC:58273};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000007186.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000007186.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007186.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000007186.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007186.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6YZ64; -.
DR STRING; 9796.ENSECAP00000007186; -.
DR PaxDb; 9796-ENSECAP00000007186; -.
DR Ensembl; ENSECAT00000009440.3; ENSECAP00000007186.2; ENSECAG00000009091.4.
DR VGNC; VGNC:58273; WDR74.
DR GeneTree; ENSGT00390000015119; -.
DR HOGENOM; CLU_033769_2_0_1; -.
DR InParanoid; F6YZ64; -.
DR OMA; EHGMSFA; -.
DR OrthoDB; 70739at2759; -.
DR TreeFam; TF314666; -.
DR Proteomes; UP000002281; Chromosome 12.
DR Bgee; ENSECAG00000009091; Expressed in inner cell mass and 23 other cell types or tissues.
DR ExpressionAtlas; F6YZ64; baseline.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR CDD; cd22857; WDR74; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR037379; WDR74/Nsa1.
DR PANTHER; PTHR16038; NOP SEVEN ASSOCIATED PROTEIN 1; 1.
DR PANTHER; PTHR16038:SF4; WD REPEAT-CONTAINING PROTEIN 74; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT REGION 323..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..344
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 385 AA; 42642 MW; 6C6E34C3D58B273C CRC64;
MAAAGARWNH VWIGTETGIL KGVNLQRKQA ANFTATGQPR REEAVSALCW GAGGETQILV
GCADRTVRHF SIEEGRFQGQ RHCPGGEGTF RGLAQVDGTL ITCVDSGILR VWHDNDKEAS
SDPLLELRVG PGVCRMRQDP AHPHVVATGG KENALKVWDL QGSEEPVFRA KNVRNDWLDL
RVPIWDQDIQ FLPESQKLVT CTGYHQVRVY DPASPQRRPV LEATYGEYPL TAMTLTPGGN
SVIVGNTHGQ LAEIDLRQGR LLGCLKGLAG SVRGLQCHPS KPLLASCGLD RVLRVHRIRN
PRGLEHKVYL KSQLNCLLLS GRDNWEDEPQ EPQEPKKVPP EDTETDELWA SLEAAAKRRL
PDLEQTQGVL QTKRRKKKRP GSTSP
//
