ID F6YZM5_HORSE Unreviewed; 614 AA.
AC F6YZM5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Glutathione S-transferase C-terminal domain-containing protein {ECO:0000256|ARBA:ARBA00022165};
GN Name=GSTCD {ECO:0000313|Ensembl:ENSECAP00000007761.3,
GN ECO:0000313|VGNC:VGNC:18625};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000007761.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000007761.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007761.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000007761.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007761.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GSTCD family.
CC {ECO:0000256|ARBA:ARBA00008797}.
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DR AlphaFoldDB; F6YZM5; -.
DR STRING; 9796.ENSECAP00000007761; -.
DR PaxDb; 9796-ENSECAP00000007761; -.
DR Ensembl; ENSECAT00000010096.3; ENSECAP00000007761.3; ENSECAG00000009590.3.
DR VGNC; VGNC:18625; GSTCD.
DR GeneTree; ENSGT00390000004446; -.
DR HOGENOM; CLU_013673_1_0_1; -.
DR InParanoid; F6YZM5; -.
DR OMA; PRNRIYT; -.
DR TreeFam; TF324238; -.
DR Proteomes; UP000002281; Chromosome 2.
DR Bgee; ENSECAG00000009590; Expressed in inner cell mass and 23 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR CDD; cd00299; GST_C_family; 1.
DR Gene3D; 1.20.1050.10; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR025714; Methyltranfer_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR13369:SF0; GLUTATHIONE S-TRANSFERASE C-TERMINAL DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR13369; UNCHARACTERIZED; 1.
DR Pfam; PF13679; Methyltransf_32; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS50405; GST_CTER; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 210..345
FT /note="GST C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50405"
FT REGION 186..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 614 AA; 68852 MW; 3F691DE57B01012E CRC64;
MKGIKKNLTE EYLYLDFSHQ IEGCIFPLHT SVTLFLLSYC DCKIFKVCLV LTGESADTSL
LKNVLSQHVE IQIISRQELP LIVQNCCLPA VVESPDSFCR AGLAVVLRHI VQRAYDAEPS
KKGILELLGF KKTCLKACAE VSQWTRLCEL TIPLSIENFL KESCDQHPAI PTEILQLEKK
LSEPVRVHND DKLRRQKLKQ QKAAGAGPTL AQEKLKSQAH MQETSEDQDP SSQSLELQVA
FSKLTVQEHP AAPNREPAHI RRAGACALPP LEHVFAEGLY FTLADLVLLP CIHHFLVVIC
KKLSKRLVEF PLLAAWYQRV QEVPGVKTAA SRCGIQFLHL PELPTTSIEQ HPKFSEAAGA
EEHSDPSFIG GPRPTMTKLM EKGIEVMFSP HPCPAWTLDW NRLPAAVSPK EGKMSSDRAL
RKQQQLNNLV YVVTHQARPG DRIVDFCSGG GHVGIVLAHM LPSCQVTLIE NKELSLIRAK
KRSDELGLSN IWFIQANMEY FTGMFNIGVA LHACGVATDM VIEHCIKTRA SFVTCPCCYG
FVQNTSKFSF PKSEQFKKTL SYKEHMILCR FADQTAVQLP PQRRLIGKQC MCLVDLDRAR
AAEERGYSVQ VWFI
//
