ID F6Z923_XENTR Unreviewed; 414 AA.
AC F6Z923;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Growth differentiation factor 7 {ECO:0000313|Ensembl:ENSXETP00000019537};
DE SubName: Full=Growth/differentiation factor 7 {ECO:0000313|RefSeq:XP_002934530.1};
GN Name=gdf7 {ECO:0000313|Ensembl:ENSXETP00000019537,
GN ECO:0000313|RefSeq:XP_002934530.1,
GN ECO:0000313|Xenbase:XB-GENE-484925};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000019537};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000019537}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000019537};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000019537}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_002934530.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_002934530.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_002934530.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_002934530.1; XM_002934484.5.
DR Ensembl; ENSXETT00000019537; ENSXETP00000019537; ENSXETG00000008906.
DR GeneID; 100496775; -.
DR KEGG; xtr:100496775; -.
DR AGR; Xenbase:XB-GENE-484925; -.
DR CTD; 151449; -.
DR Xenbase; XB-GENE-484925; gdf7.
DR eggNOG; KOG3900; Eukaryota.
DR HOGENOM; CLU_020515_0_0_1; -.
DR OMA; RAPRAFC; -.
DR OrthoDB; 2912454at2759; -.
DR TreeFam; TF316134; -.
DR Proteomes; UP000008143; Chromosome 5.
DR Bgee; ENSXETG00000008906; Expressed in 4-cell stage embryo and 1 other cell type or tissue.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd13766; TGF_beta_GDF5_6_7; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF160; GROWTH_DIFFERENTIATION FACTOR 7; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..414
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041197317"
FT DOMAIN 289..414
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 269..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 414 AA; 46562 MW; EAE0DB2779261F00 CRC64;
MDLRKAAALR LGLCSVWLWA LQAAASVLPS SHRLTLPGGT RRALAALHGH PKDHLLFSKE
PMGKGTVVPH EYMLALYKSL SGTEHRELGR STARNRSRAN TITSFVDQGH DDLPPQPPEQ
KFLFDTRSLP ERDEIVGAEL RILRRFPLDA SSISGLGSLV HLNLYTCPTG WQEPKLIDSR
SADLLDTVFS KWEVFNVWKA LGNRRLSGET LCFMLKIVSD IKATAFQPVQ MGFSREGQQP
HEKALLVVSS HSKRRENLFK EIRDKIKSMG NPKFLEPPDS GQQSIPKRRR KRTTLPTRTN
NGKGQGKKSK TRCSKKPLHV NFKELGWDDW IIAPLDYEAY HCEGVCDFPL RSHLEPTNHA
IIQTLMNSMD PESTPPSCCV PSKLSPISIL YIDSGNNVVY KQYEDMVVES CGCR
//
