ID F6ZAG4_HORSE Unreviewed; 315 AA.
AC F6ZAG4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Serine/threonine-protein phosphatase CPPED1 {ECO:0000256|ARBA:ARBA00013356};
DE EC=3.1.3.16 {ECO:0000256|ARBA:ARBA00013081};
DE AltName: Full=Calcineurin-like phosphoesterase domain-containing protein 1 {ECO:0000256|ARBA:ARBA00032900};
GN Name=CPPED1 {ECO:0000313|Ensembl:ENSECAP00000016226.2,
GN ECO:0000313|VGNC:VGNC:16830};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000016226.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000016226.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000016226.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000016226.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000016226.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Protein phosphatase that dephosphorylates AKT family kinase
CC specifically at 'Ser-473', blocking cell cycle progression and
CC promoting cell apoptosis. May play an inhibitory role in glucose uptake
CC by adipocytes. {ECO:0000256|ARBA:ARBA00024771}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] +
CC phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:83421; EC=3.1.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001512};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:61977; EC=3.1.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001482};
CC -!- COFACTOR:
CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC Evidence={ECO:0000256|ARBA:ARBA00001968};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the metallophosphoesterase superfamily. CPPED1
CC family. {ECO:0000256|ARBA:ARBA00010567}.
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DR RefSeq; XP_005598962.1; XM_005598905.2.
DR AlphaFoldDB; F6ZAG4; -.
DR STRING; 9796.ENSECAP00000016226; -.
DR PaxDb; 9796-ENSECAP00000016226; -.
DR Ensembl; ENSECAT00000019796.4; ENSECAP00000016226.2; ENSECAG00000018687.4.
DR VGNC; VGNC:16830; CPPED1.
DR GeneTree; ENSGT00390000008676; -.
DR HOGENOM; CLU_077151_0_0_1; -.
DR InParanoid; F6ZAG4; -.
DR OMA; NEPTHET; -.
DR TreeFam; TF329406; -.
DR Proteomes; UP000002281; Chromosome 13.
DR Bgee; ENSECAG00000018687; Expressed in testis and 23 other cell types or tissues.
DR ExpressionAtlas; F6ZAG4; baseline.
DR GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR CDD; cd07395; MPP_CSTP1; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR041867; MPP_CSTP1.
DR PANTHER; PTHR43143; METALLOPHOSPHOESTERASE, CALCINEURIN SUPERFAMILY; 1.
DR PANTHER; PTHR43143:SF1; SERINE_THREONINE-PROTEIN PHOSPHATASE CPPED1; 1.
DR Pfam; PF00149; Metallophos; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE 1: Evidence at protein level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F6ZAG4};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 73..249
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
SQ SEQUENCE 315 AA; 35603 MW; B1BAAACE437B87E5 CRC64;
MSTAEARGVF HRARGRTLDA FPSEKEREWK GPFYFIQGAD PQFGLMKAWS TGECDSGGDE
WGQETRLTEQ AVRAVNRLNP KPKFFVLCGD LVHAMPGMPW RKEQTEDLQR VLRDVDSEIP
LVFVSGNHDV GNVPTPETIE EFQQTWGDDY FSFWVGGVLF LVLNSQFLYD ASRCPALKQA
QDQWLDQQLS IAGQRKCQHA IVFQHIPLFL ESIDEDDDYF NLSKPVRKEM VDKLSKAGVK
AVFSGHYHRN AGGIYQNLDM VVSSAIGCQL GKDTHGLRVV VVTAEKIVHR NSSCRQPLIE
YKSVPGRFVN LCSFA
//
