ID F6ZNI9_HORSE Unreviewed; 623 AA.
AC F6ZNI9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Kelch repeat and BTB domain containing 12 {ECO:0000313|Ensembl:ENSECAP00000009045.2};
GN Name=KBTBD12 {ECO:0000313|Ensembl:ENSECAP00000009045.2,
GN ECO:0000313|VGNC:VGNC:19254};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000009045.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000009045.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000009045.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000009045.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000009045.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_001488910.1; XM_001488860.3.
DR AlphaFoldDB; F6ZNI9; -.
DR SMR; F6ZNI9; -.
DR STRING; 9796.ENSECAP00000009045; -.
DR PaxDb; 9796-ENSECAP00000009045; -.
DR Ensembl; ENSECAT00000011559.3; ENSECAP00000009045.2; ENSECAG00000011193.3.
DR GeneID; 100053890; -.
DR KEGG; ecb:100053890; -.
DR CTD; 166348; -.
DR VGNC; VGNC:19254; KBTBD12.
DR GeneTree; ENSGT00940000156836; -.
DR HOGENOM; CLU_004253_14_2_1; -.
DR InParanoid; F6ZNI9; -.
DR OMA; DYWRDGP; -.
DR OrthoDB; 5472491at2759; -.
DR TreeFam; TF351656; -.
DR Proteomes; UP000002281; Chromosome 16.
DR Bgee; ENSECAG00000011193; Expressed in gluteus medius and 21 other cell types or tissues.
DR CDD; cd18485; BACK_KBTBD12; 1.
DR CDD; cd18276; BTB_POZ_KBTBD12; 1.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412; KELCH PROTEIN; 1.
DR PANTHER; PTHR24412:SF459; KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 12; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 4.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 4.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 4: Predicted;
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 31..98
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
SQ SEQUENCE 623 AA; 71149 MW; 62FCD14CC3B4DFAE CRC64;
MECKIQGKEK YQHSLNLLNK VKNMKELAEM VDVVLIAEGE KFPCHRLVLA AFSPYFKAMF
TCGLLECTQR EVILYDITAE SVSVILNYMY SATLEINNAN VQTVAMAAYF MQMEEVFSVC
QKYMMDHMDA SNCVGIYYFA KQIGAEDLSD QSKKYLYQHF AEVSLHEEIL ETEVHQFLTL
VKSDDLNISR EESILDLVLK WVNHNRELRT VHLVELLKQV RLELINPSFL RQALKRNTML
LCDAGCIDII QNAFKAIKTP QQHSLNLRYG METTSLLLCI GNNSSGIRSR HRNYGDASFC
YDPASRKTYF ISSPKYGEGL GNVCTGVVME NNTIIVAGEA SASKLSRQRN KNVEIYRYHV
RGNQFWEKLC TTEFRELYAL GSVRNDLYVI GGQMKMKNQY LITNCVDKYS VERDNWKRVS
PLPLQLACHA VVTVNNKLYV IGGWTPQMDL PDEEPDRLSN KLLQYDPNQD QWTERAPMKY
SKYRFSTAVV NSEIYVLGGI GCVGRDKGQV RKCLDVVEIY NPDGDFWREG PPMPSPLLSL
RTNSTNAGTV DGKLYVCGGF HGADRHEVIS KEILELDPWE NQWNVVAINV LMHDSYDVCL
VARMNPRDLI PPPSDLVEEG NEH
//
