ID F6ZP40_MONDO Unreviewed; 1095 AA.
AC F6ZP40;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=SKI family transcriptional corepressor 2 {ECO:0000313|Ensembl:ENSMODP00000004137.4};
GN Name=SKOR2 {ECO:0000313|Ensembl:ENSMODP00000004137.4};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000004137.4, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000004137.4, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000004137.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SKI family. {ECO:0000256|ARBA:ARBA00009513}.
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DR RefSeq; XP_001371727.3; XM_001371690.4.
DR AlphaFoldDB; F6ZP40; -.
DR STRING; 13616.ENSMODP00000004137; -.
DR Ensembl; ENSMODT00000004223.4; ENSMODP00000004137.4; ENSMODG00000003381.4.
DR GeneID; 100018545; -.
DR KEGG; mdo:100018545; -.
DR CTD; 652991; -.
DR eggNOG; ENOG502QQC2; Eukaryota.
DR GeneTree; ENSGT00940000160474; -.
DR HOGENOM; CLU_011930_1_0_1; -.
DR InParanoid; F6ZP40; -.
DR OMA; QLQIVRC; -.
DR OrthoDB; 2898797at2759; -.
DR TreeFam; TF324133; -.
DR Proteomes; UP000002280; Chromosome 3.
DR Bgee; ENSMODG00000003381; Expressed in cerebellum and 5 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0042826; F:histone deacetylase binding; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0046332; F:SMAD binding; IBA:GO_Central.
DR GO; GO:0048468; P:cell development; IEA:Ensembl.
DR GO; GO:0021702; P:cerebellar Purkinje cell differentiation; IEA:Ensembl.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IEA:Ensembl.
DR GO; GO:0021936; P:regulation of cerebellar granule cell precursor proliferation; IEA:Ensembl.
DR GO; GO:0048814; P:regulation of dendrite morphogenesis; IEA:Ensembl.
DR GO; GO:1902692; P:regulation of neuroblast proliferation; IEA:Ensembl.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
DR CDD; cd21080; DHD_Skor; 1.
DR Gene3D; 3.10.390.10; SAND domain-like; 1.
DR Gene3D; 3.10.260.20; Ski; 1.
DR InterPro; IPR014890; c-SKI_SMAD4-bd_dom.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR010919; SAND-like_dom_sf.
DR InterPro; IPR003380; SKI/SNO/DAC.
DR InterPro; IPR037000; Ski_DNA-bd_sf.
DR InterPro; IPR023216; Tscrpt_reg_SKI_SnoN.
DR PANTHER; PTHR10005:SF7; SKI FAMILY TRANSCRIPTIONAL COREPRESSOR 2; 1.
DR PANTHER; PTHR10005; SKI ONCOGENE-RELATED; 1.
DR Pfam; PF08782; c-SKI_SMAD_bind; 1.
DR Pfam; PF02437; Ski_Sno; 1.
DR SMART; SM01046; c-SKI_SMAD_bind; 1.
DR SUPFAM; SSF46955; Putative DNA-binding domain; 1.
DR SUPFAM; SSF63763; SAND domain-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002280}.
FT DOMAIN 176..268
FT /note="c-SKI SMAD4-binding"
FT /evidence="ECO:0000259|SMART:SM01046"
FT REGION 45..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 551..1014
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..331
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..349
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..597
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..739
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..786
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 800..815
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 823..848
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 903..918
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 920..943
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 989..1014
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1095 AA; 114091 MW; 68D4BCF8D9221203 CRC64;
MTMALFWQMG YTGMKLYKQD QGESIRGPTV EEMATSPLPG PNDILLASPS SAYQPDPLSQ
PRPGHASMKP NQVGQVILYG IPIVSLVIDG QERLCLAQIS NTLLKNFSYN EIHNRRVALG
ITCVQCTPVQ LEILRRAGAM PISSRRCGMI TKREAERLCK SFLGENRPPK LPDNFAFDVS
HECAWGCRGS FIPARYNSSR AKCIKCSYCN MYFSPNKFIF HSHRTPEAKY TQPDAANFNS
WRRHLKLTDK SPQDELVFAW EDVKAMFNGG SRKRALPQPG SHPACHPLSS VKAAAAAAAA
AAAVAGGGGL LGPHLLGAPP PPPPPPPLAE LAGGPHSHHK RPRFDDDEDS LQEAAVVAAA
SLSAAAASLS AAAAAGSAGV GVAGGGGGGA GSGGVGGVGA GGTGGPGGGS KGPRSYPVIP
VPSKGSFGGV LQKFPGCGGL FPHPYTFPAA AAFGLCHKKE DGAAGAEALG GGGGGAGGGA
GGAQKAGLSG LFWPTGRKDA FYPPFCMFWP PRTPGGLPVP TYLQPPPQPP TALSCALGDS
PALLRQAFLD LAEPGGGGGG GGGGGGAGGG GGNGASSTEA PPAPGQPQPP TAANGANSGP
PPQPSGGAGT RDALFESPSG SGDCSAGSTP PAEGAGGAGG GGGTKGSRVP APHHPHLLEG
PGGRKAGGGT GGSSSSGYHH SSAFRPVGGK DDSESLAKLH GASAGAGGQH HPHPPHHHHH
HHHHPHHHHH HHHHHHHPQP PSPLLLLQQP EEPGPERHHP APPPPPPPPP PPPPPPPPPP
PQPHHRLLSP GGTSCSYPSE DSSEDEDDEE EEQEVDVEGH KPPEGEEEDE EEDGRDPEEE
DEEEEGGGMM LGDPLVGGSR YLQGRGLTEK GGSRDRPSGS FPLVLNTSRL QQEEEKLGDQ
GSPDLHPPPP PPLPPPLATQ KGGSGSSSSS GGSSPSSPVH HPSLEEQPSY KDNQKTKEGN
PVILPTKEDS FSDKNKEHNF FITDSETSGG DFWRERAGEH TQETNSPHSL KKDVENMGKE
ELQKVLFEQI DLRRRLEQEF QVLKGNASFP VFNNFQDQMK RELAYREEMV QQLQIIPYAA
SLIRKEKLGT HLSKS
//
