ID F6ZQL4_HORSE Unreviewed; 198 AA.
AC F6ZQL4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=PYM homolog 1, exon junction complex associated factor {ECO:0000313|Ensembl:ENSECAP00000009678.3};
GN Name=PYM1 {ECO:0000313|Ensembl:ENSECAP00000009678.3,
GN ECO:0000313|VGNC:VGNC:22066};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000009678.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000009678.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000009678.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000009678.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000009678.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Interacts (via N-terminus) with magoh and rbm8a; the
CC interaction is direct. Associates (eIF2A-like region) with the 40S
CC ribosomal subunit and the 48S preinitiation complex.
CC {ECO:0000256|ARBA:ARBA00025900}.
CC -!- SIMILARITY: Belongs to the pym family. {ECO:0000256|ARBA:ARBA00009394}.
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DR AlphaFoldDB; F6ZQL4; -.
DR Ensembl; ENSECAT00000012269.3; ENSECAP00000009678.3; ENSECAG00000011870.4.
DR VGNC; VGNC:22066; PYM1.
DR GeneTree; ENSGT00730000111107; -.
DR HOGENOM; CLU_074603_3_0_1; -.
DR OrthoDB; 1216579at2759; -.
DR TreeFam; TF324615; -.
DR Proteomes; UP000002281; Chromosome 6.
DR Bgee; ENSECAG00000011870; Expressed in endometrium and 23 other cell types or tissues.
DR ExpressionAtlas; F6ZQL4; baseline.
DR GO; GO:1903259; P:exon-exon junction complex disassembly; IEA:InterPro.
DR InterPro; IPR039333; PYM1.
DR InterPro; IPR015362; WIBG_mago-bd.
DR InterPro; IPR036348; WIBG_N_sf.
DR PANTHER; PTHR22959:SF0; PARTNER OF Y14 AND MAGO; 1.
DR PANTHER; PTHR22959; PYM PROTEIN; 1.
DR Pfam; PF09282; Mago-bind; 1.
DR SMART; SM01273; Mago-bind; 1.
DR SUPFAM; SSF101931; Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 6..32
FT /note="WIBG Mago-binding"
FT /evidence="ECO:0000259|SMART:SM01273"
FT REGION 49..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 198 AA; 22303 MW; DDC61B2620081C4C CRC64;
MFYLPTGKYI ASTQRPDGTW RKQRRVKEGY VPQEEVPVYE NKYVKFFKSK PELPPGLSPE
ATVPVTPSRP EGGEPGLSKT AKRNLKRKEK RRQQQEKGEA EALSRTLDKV SLGETAQVPS
APQGSRPAPT AASDQPDSTA TTEKAKKIKN LKKKLRQVEE LQQRIQAGEI SQPSKEQLEK
LARRRALEEE LEDLELGL
//
