ID   F6ZWM2_ORNAN            Unreviewed;      1147 AA.
AC   F6ZWM2;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 2.
DT   27-MAR-2024, entry version 68.
DE   SubName: Full=Tetratricopeptide repeat domain 7A {ECO:0000313|Ensembl:ENSOANP00000003279.2};
GN   Name=TTC7A {ECO:0000313|Ensembl:ENSOANP00000003279.2};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000003279.2, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Ensembl:ENSOANP00000003279.2}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000003279.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; F6ZWM2; -.
DR   STRING; 9258.ENSOANP00000003279; -.
DR   Ensembl; ENSOANT00000003280.2; ENSOANP00000003279.2; ENSOANG00000002071.3.
DR   eggNOG; KOG4162; Eukaryota.
DR   GeneTree; ENSGT00940000158638; -.
DR   HOGENOM; CLU_040496_0_0_1; -.
DR   Proteomes; UP000002279; Unplaced.
DR   Bgee; ENSOANG00000002071; Expressed in testis and 7 other cell types or tissues.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR045819; TTC7_N.
DR   PANTHER; PTHR23083:SF475; TETRATRICOPEPTIDE REPEAT PROTEIN 7A; 1.
DR   PANTHER; PTHR23083; TETRATRICOPEPTIDE REPEAT PROTEIN, TPR; 1.
DR   Pfam; PF13432; TPR_16; 1.
DR   Pfam; PF13181; TPR_8; 1.
DR   Pfam; PF19440; TTC7_N; 2.
DR   SMART; SM00028; TPR; 7.
DR   SUPFAM; SSF48452; TPR-like; 3.
DR   PROSITE; PS50005; TPR; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   DOMAIN          373..527
FT                   /note="Tetratricopeptide repeat protein 7 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19440"
FT   DOMAIN          543..692
FT                   /note="Tetratricopeptide repeat protein 7 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19440"
FT   REPEAT          1034..1067
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          1102..1135
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REGION          1..362
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          930..964
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..26
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        69..85
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        86..101
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        102..122
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        131..173
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        197..239
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        247..279
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        293..312
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        313..330
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1147 AA;  128872 MW;  542F82C8608E70E6 CRC64;
     MREGPDPPGT HRQIDRHTHT HTHTQTDRQP CDVPGAGPGP GPAGEEEERR RRRRRKRGGA
     AGGGAGEGGG REEQEKEEEE RRKSSSRRRR SRRRRKRGGG AARGAGGREE EQQEEEEERR
     SRRRRRKRGG GAGGGGREEE QEEEEERRSR RKRGGAGGRE EQQQEEEEER RSRRRRRKRG
     GGAGGGGREE EEGQEQEEEG RSRRRKKRGG AGGREEEQEE ERSSSRRRKK RGGAGEGGGR
     EEEEQEEEEE RRSRRRKKRG GAGGREEQQQ EEEEERRSRR RRSRRRRKRG GGGAGAGGRE
     EEQEEEEERR RSRKSSRRRR SSRRRRSSRK GGGGGREEEE EQQEEEEGRR RRRSRAAEVR
     VGRMSASGVP GWSRQKVEAE LERCRARCHW GPVPTLVLQL QTLAFAAPAA GHTDDFGKLL
     LAEALLEQSL KENIAQIKDA VPLLEKSESK LGEAKKYLTG ILTRGRLPPK YTREAMLILG
     KLHFAEGSYR EAVSMYARAG IDAMTVENKP LYQLRLVAEA FVIKALSSSL LGGRQLRWPQ
     VLDGNIVKGL RELREVLRTV ETKATQNFKM TAAKQLAGVL LHSLSEDCYW SPLSLPLPDF
     VTKEETGFVT QALRKPHLYT GDNLYCPQDN IEEALLLLLI SESMANRDAV LSRAPDQKED
     RAVSLRDASA VYDLLSITLG RRGQYVMLSE CLERAMKFAC EEFHLWYQLA LSMVACGKCA
     YAVSILRECA KLRPEDPTVP LLAAKVCIEP LHWLEEAERF AQTVVDMGDA AGEFLAKGYL
     ALGLTYSLQA TDATLKGTQD QLHKKALETL ERARQLAPED HQVILYMSLQ LALVRQIPEA
     TECLQQALKV CRDDANSLHL LALLFSAQKH YQHALDIIDM AIGEYPENFS LLFTKVKLEQ
     VVCGPEEALV TCRHLLRTWQ ALHGVSQLGD SEKESSVAEG PLVRKPSGLH LTLPDAHDTD
     SGSQRASSIA ASRLEQAMSE VTMRNSTLKQ GPVQLWTTLE RIWLQAAELF MAQRHLKEAA
     SCVQEASSLF PTSHTVLHTR GKLAEMRGRL EEAKQLYDEA LTINPDGQEI MSSLGLILSR
     LGRQCLAQKV LRDATRVCST SHEAWNSLGQ VLQGQGHSQA AAECFLTALD LEASSPVVPF
     TTIPREL
//