ID F7A7C6_CALJA Unreviewed; 284 AA.
AC F7A7C6;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Zinc transporter ZIP9 {ECO:0000256|ARBA:ARBA00026135, ECO:0000256|RuleBase:RU369011};
DE Short=ZIP-9 {ECO:0000256|RuleBase:RU369011};
DE AltName: Full=Solute carrier family 39 member 9 {ECO:0000256|ARBA:ARBA00031674, ECO:0000256|RuleBase:RU369011};
DE AltName: Full=Zrt- and Irt-like protein 9 {ECO:0000256|ARBA:ARBA00031377, ECO:0000256|RuleBase:RU369011};
GN Name=SLC39A9 {ECO:0000313|Ensembl:ENSCJAP00000042443.3};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000042443.3, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000042443.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000042443.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Transports zinc ions across cell and organelle membranes into
CC the cytoplasm and regulates intracellular zinc homeostasis.
CC Participates in the zinc ions efflux out of the secretory compartments.
CC Also functions as membrane androgen receptor that mediates, through a G
CC protein, the non-classical androgen signaling pathway, characterized by
CC the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1
CC or ATF1. Moreover, has dual functions as membrane-bound androgen
CC receptor and as an androgen-dependent zinc transporter both of which
CC are mediated through an inhibitory G protein (Gi) that mediates both
CC MAP kinase and zinc signaling leading to the androgen-dependent
CC apoptotic process. {ECO:0000256|RuleBase:RU369011}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351,
CC ChEBI:CHEBI:29105; Evidence={ECO:0000256|ARBA:ARBA00034634};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU369011};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU369011}. Cytoplasm,
CC perinuclear region {ECO:0000256|ARBA:ARBA00004556,
CC ECO:0000256|RuleBase:RU369011}. Golgi apparatus, trans-Golgi network
CC membrane {ECO:0000256|ARBA:ARBA00004198,
CC ECO:0000256|RuleBase:RU369011}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC {ECO:0000256|ARBA:ARBA00004173, ECO:0000256|RuleBase:RU369011}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU369011}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000256|RuleBase:RU369011}.
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DR AlphaFoldDB; F7A7C6; -.
DR Ensembl; ENSCJAT00000052269.3; ENSCJAP00000042443.3; ENSCJAG00000014935.5.
DR GeneTree; ENSGT00390000010094; -.
DR Proteomes; UP000008225; Chromosome 10.
DR Bgee; ENSCJAG00000014935; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR003689; ZIP.
DR InterPro; IPR045891; ZIP9.
DR PANTHER; PTHR16133; SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED; 1.
DR PANTHER; PTHR16133:SF5; ZINC TRANSPORTER ZIP9; 1.
DR Pfam; PF02535; Zip; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Glycoprotein {ECO:0000256|RuleBase:RU369011};
KW Ion transport {ECO:0000256|RuleBase:RU369011};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU369011};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU369011};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU369011}; Transport {ECO:0000256|RuleBase:RU369011};
KW Zinc {ECO:0000256|RuleBase:RU369011};
KW Zinc transport {ECO:0000256|RuleBase:RU369011}.
FT TRANSMEM 6..28
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369011"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369011"
FT TRANSMEM 104..122
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369011"
FT TRANSMEM 153..175
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369011"
FT TRANSMEM 187..206
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369011"
FT TRANSMEM 218..240
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369011"
FT TRANSMEM 260..281
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369011"
SQ SEQUENCE 284 AA; 29982 MW; 67E9F51E7914B792 CRC64;
MDDFISISLL SLAMLVGCYV AGIIPLAVNF SEERLKLVTV LGAGLLCGTA LAVIVPEGVH
ALYEDILEGK HHQASETHNV IASDKAAEMS VVHEHEHSHD HTQLHAYIGV SLVLGFVFML
LVDQIGNSHV HSTDADGVAL GAAASTSQTS VQLIVFVAIM LHKAPAAFGL VSFLMHAGLE
RNRIRKHLLV FALAAPVMSM VTYLGLSKSS KEALSEVNAT GVAMLFSAGT FLYVATVHVL
PEVGGMGHSH KPDTTGGRGL SRLEVAALVL GCLIPLILSV GHQH
//
