ID F7AGJ0_ORNAN Unreviewed; 844 AA.
AC F7AGJ0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Bicarbonate transporter-like transmembrane domain-containing protein {ECO:0000259|Pfam:PF00955};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000008969.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000008969.2, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000008969.2,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000008969.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000008969.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993}.
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DR AlphaFoldDB; F7AGJ0; -.
DR STRING; 9258.ENSOANP00000008969; -.
DR Ensembl; ENSOANT00000008971.2; ENSOANP00000008969.2; ENSOANG00000038848.1.
DR eggNOG; KOG1172; Eukaryota.
DR GeneTree; ENSGT00940000154894; -.
DR HOGENOM; CLU_002289_6_3_1; -.
DR InParanoid; F7AGJ0; -.
DR OMA; TNWTVIK; -.
DR TreeFam; TF313630; -.
DR Proteomes; UP000002279; Chromosome 1.
DR GO; GO:0016323; C:basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006820; P:monoatomic anion transport; IEA:InterPro.
DR GO; GO:0050801; P:monoatomic ion homeostasis; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF82; SOLUTE CARRIER FAMILY 4 MEMBER 11; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 335..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 378..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 416..436
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 448..467
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 528..546
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 566..583
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 603..629
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 649..669
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 770..789
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 306..691
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
SQ SEQUENCE 844 AA; 93807 MW; 1E9B8A5F989CBEBC CRC64;
NMPLTAVYAN ELSSPHSPAS SVSGFYSFVP TDPTGYLNCD TDDGGEANEG SPGDELFDTV
NSSLVSGDSI CFLVDVNLEV QQNFEEEIRA HRKLDGFLPW ASILLGETAT PLDDVLCKLL
RHFTEDADST EPNCNFDKIM IGSPLDTACL CLPGPPSLII QGMTATVMGV QYQQSWLCIV
CTIKTLQRCH ICISRLEQPQ NWGENSCEVS IVILMLAPPE MVSAPMEVGR NFATVFFDIT
FHLKLLETKT EEEFKEALVH QPYLLTMVNQ HLPAGFSETL KESGPPGPDP YASFLPQLND
FFWVRKGILD DIAQRFPMFA LDLTYVRSNK AVGKYITTMM FLYFDCLLPT IAFGSLNDEN
THGSIDVQKT IVGQCISGLL YALFTGQPLV VLLTTTPLVL YINVIQGICD DYSLDFHIYA
WTGLWNSFFL ILYAVFNFSL LMKLFKRWII ALFISITFVL DPIKGIITSE SRPPSHLQCL
HSPGLSSRRL PSLSLNTTLV VNLSFGGSLC PQNQTGGHEL AHYRQETAVL SLMNMLGTLW
LGHTLYQFKK TPTCMHAHIR EILSDCAVLI SVLTFSLVGS YFFQEIEISK FSYNPSENLL
ELAPVHLLSS GVALRAMGLG FLMSMFFFIE QNIVASPNHR LVKGTAYHWD LLLVALINTG
LFLFGLPWIH AAYPHSPMHV RALAFVKEHC EGDSTDHPGG QRPGGVVPPA AALPAAVDPV
VYGLFLYIAL TSIDGLVNPT RAHPVTPRSL SPQTAYSPVH CIWRVPQRTI HYFTVLQVLQ
LLLLCMFGMS PLPYMKMIFP LIMIAMIPIR CPPLPPPRGT FRSLPRGWGA FGPISFSHLF
NLIY
//
