ID F7B1U9_HORSE Unreviewed; 495 AA.
AC F7B1U9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=BAR/IMD domain containing adaptor protein 2 like 2 {ECO:0000313|Ensembl:ENSECAP00000016334.3};
GN Name=BAIAP2L2 {ECO:0000313|VGNC:VGNC:56399};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000016334.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000016334.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000016334.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000016334.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000016334.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F7B1U9; -.
DR STRING; 9796.ENSECAP00000016334; -.
DR PaxDb; 9796-ENSECAP00000016334; -.
DR Ensembl; ENSECAT00000019919.4; ENSECAP00000016334.3; ENSECAG00000018782.4.
DR VGNC; VGNC:56399; BAIAP2L2.
DR GeneTree; ENSGT00940000153560; -.
DR HOGENOM; CLU_025877_1_1_1; -.
DR InParanoid; F7B1U9; -.
DR OMA; QNLMEHF; -.
DR OrthoDB; 3059844at2759; -.
DR TreeFam; TF325648; -.
DR Proteomes; UP000002281; Chromosome 28.
DR Bgee; ENSECAG00000018782; Expressed in adult mammalian kidney and 11 other cell types or tissues.
DR GO; GO:0044291; C:cell-cell contact zone; IEA:Ensembl.
DR GO; GO:0071439; C:clathrin complex; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0012506; C:vesicle membrane; IEA:Ensembl.
DR GO; GO:0005543; F:phospholipid binding; IEA:Ensembl.
DR GO; GO:0051764; P:actin crosslink formation; IBA:GO_Central.
DR GO; GO:0051017; P:actin filament bundle assembly; IBA:GO_Central.
DR GO; GO:0007009; P:plasma membrane organization; IEA:InterPro.
DR GO; GO:0030838; P:positive regulation of actin filament polymerization; IBA:GO_Central.
DR CDD; cd07644; I-BAR_IMD_BAIAP2L2; 1.
DR CDD; cd11914; SH3_BAIAP2L2; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR030126; Baiap2l2_I-BAR_dom.
DR InterPro; IPR013606; I-BAR_dom.
DR InterPro; IPR027681; IRSp53/IRTKS/Pinkbar.
DR InterPro; IPR035593; Pinkbar_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR14206; BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 1-ASSOCIATED PROTEIN 2; 1.
DR PANTHER; PTHR14206:SF5; BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 1-ASSOCIATED PROTEIN 2-LIKE PROTEIN 2; 1.
DR Pfam; PF08397; IMD; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51338; IMD; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..222
FT /note="IMD"
FT /evidence="ECO:0000259|PROSITE:PS51338"
FT DOMAIN 309..372
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 204..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 395..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 401..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..459
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 495 AA; 55282 MW; 236D906F52E965D0 CRC64;
MAPEMDQFYR STVAIYKSIM EQFNPALENL VYLGNNYLRA FHALSEAAEV YFSAIQKIGE
QALQSPTSQI LGEILVQTFH GDLLQHMEKN TKLDMQFIKD SRQHYEIEYR HRAANLEKCM
SELWHMERKR DKNAREMKES VNRLHAQMQA FVSESQRAAE LEEKRRYRFL AEKHLLLSNT
FLQFFGRARG MLQNRVLLWK EQSEASRSPS RAHSPGLLGP VLGPPYPSGR LTPTRLDMPP
RPLGEFGSPR SRHGSGSYGP EPTDARSASQ LEPDRRSLPR TPSASSLYAG SAQPSRSNSF
GERPGGGGGG ARKVRALVSH SEGANHTLLR FSAGDVVEVL VPQAKNGWLY GKLEGSSTSG
WFPEAYVKPL EEMPMNPLNP MNELPARSYP LRGSHSLDDL LDRPGNSTAS SEHWDGQSRS
RTPSRVPSRA PSPAPTPLPG SRRSSMGNMG VTSDVKKLTS WEQPPPELFP RGTNPFATVK
LRPTVTNDRS APLIR
//
