ID F7B7A4_CIOIN Unreviewed; 546 AA.
AC F7B7A4; A0A1W5BP99;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=TGF-beta family profile domain-containing protein {ECO:0000259|PROSITE:PS51362};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000008362.3, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000008362.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; EAAA01001407; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018672306.1; XM_018816761.1.
DR AlphaFoldDB; F7B7A4; -.
DR STRING; 7719.ENSCINP00000008362; -.
DR Ensembl; ENSCINT00000008362.3; ENSCINP00000008362.3; ENSCING00000004054.3.
DR GeneTree; ENSGT00940000165321; -.
DR HOGENOM; CLU_020515_4_2_1; -.
DR InParanoid; F7B7A4; -.
DR OMA; DRLQPCQ; -.
DR TreeFam; TF316134; -.
DR Proteomes; UP000008144; Chromosome 2.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd13765; TGF_beta_ADMP; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR PANTHER; PTHR11848:SF280; TGF_BETA_2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 417..546
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 293..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..332
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..354
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 546 AA; 62173 MW; EFFFB108D431C61E CRC64;
MYLRQITYTL MMVVCMIAAK PRYRKQKRTT EVVSRRFSNP FFHQSSDIKS ADGSMATKLK
NAMKNLPENV KDDAIHEFLN MFGLQAPDNA NSIQQIKKPP KYMVDLYNAI ADQDGVTRAP
DLLDADTVRS IPNIDSRCPG RCRFDLQAVG EHEVVLDAEL HLYFEKPPTR SVSSSRTSNY
MIKIYQILSD GDGEIQKTLV AGRRLPARLL GWQIFPLLTS VETWNSRKDD NLGILVECTT
DNGEVVVQRR GLKGKSPILI LFTNDSRNNI HKAKKAKAMQ VLHNAKMATI SNQKHHISAT
IADIQTSRPR RSLRNENRRQ KKNSRKSKNR QNSKHKHQEE TNVKSTEDSS FVEYVHHQTK
NTTTLSKKNN GNHDTETIYT DDQFQGQEYD SNIWETYDLD YASDGSTKPA AETSHSRHPV
STSSAHFPSF SSLSTEASAS RHCRRYPLYV DFEEMGWSGW IIHPQGYNAY HCRGKCSFPI
SQNLKPSNHA TVQSIMHTLG LGGQPVDMPC CTPDKLYDIN LLYFDHNDYV VLRRYKDMVA
ASCACR
//
