ID F7BAV4_HORSE Unreviewed; 278 AA.
AC F7BAV4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Serine peptidase inhibitor, Kunitz type 2 {ECO:0000313|Ensembl:ENSECAP00000009174.3};
GN Name=SPINT2 {ECO:0000313|Ensembl:ENSECAP00000009174.3,
GN ECO:0000313|VGNC:VGNC:49270};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000009174.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000009174.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000009174.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000009174.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000009174.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F7BAV4; -.
DR STRING; 9796.ENSECAP00000009174; -.
DR MEROPS; I02.010; -.
DR PaxDb; 9796-ENSECAP00000009174; -.
DR Ensembl; ENSECAT00000011702.4; ENSECAP00000009174.3; ENSECAG00000011301.4.
DR VGNC; VGNC:49270; SPINT2.
DR GeneTree; ENSGT00940000160348; -.
DR HOGENOM; CLU_1274754_0_0_1; -.
DR InParanoid; F7BAV4; -.
DR OrthoDB; 3558236at2759; -.
DR TreeFam; TF326553; -.
DR Proteomes; UP000002281; Chromosome 10.
DR Bgee; ENSECAG00000011301; Expressed in trophoblast and 23 other cell types or tissues.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR CDD; cd22621; Kunitz_HAI2_1-like; 1.
DR CDD; cd22622; Kunitz_HAI2_2-like; 1.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 2.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR PANTHER; PTHR47247; KUNITZ-TYPE PROTEASE INHIBITOR 2; 1.
DR PANTHER; PTHR47247:SF1; KUNITZ-TYPE PROTEASE INHIBITOR 2; 1.
DR Pfam; PF00014; Kunitz_BPTI; 2.
DR PRINTS; PR00759; BASICPTASE.
DR SMART; SM00131; KU; 2.
DR SUPFAM; SSF57362; BPTI-like; 2.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..278
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040229749"
FT DOMAIN 38..88
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 115..165
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT REGION 202..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 278 AA; 29769 MW; 4D683A7FECF3858C CRC64;
MAPLCGPGWC RALLALLASL LVLGADAADG EQGVHEFCHV LKAVGRCRAA FPRWWYNVTD
RSCQQFVYGG CNGNKNNYLT KEECLEKCAG VTENTTDDSA ASGTRVESSV PSEYCTAKAV
TGPCRASFPR WYFNAEKNAC DSFVYGGCRG NKNSYLSKEE CMNRCFRKQL YPALPHSTKG
TCCSGLQGLS LVTSLGHGVR CPDPPSGAGR ALPDGPDPPA GSLGGLPDQG GREEPGAHPP
LRVELRGRQG APGEERLRPV SAPPSGPREG DSRMRVRF
//
