ID F7BBE8_MONDO Unreviewed; 1053 AA.
AC F7BBE8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Rho GTPase activating protein 39 {ECO:0000313|Ensembl:ENSMODP00000013918.4};
GN Name=ARHGAP39 {ECO:0000313|Ensembl:ENSMODP00000013918.4};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000013918.4, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000013918.4, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000013918.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F7BBE8; -.
DR Ensembl; ENSMODT00000014172.4; ENSMODP00000013918.4; ENSMODG00000011119.4.
DR eggNOG; ENOG502QR6X; Eukaryota.
DR GeneTree; ENSGT00390000003161; -.
DR HOGENOM; CLU_005171_0_0_1; -.
DR TreeFam; TF323577; -.
DR Proteomes; UP000002280; Chromosome 3.
DR Bgee; ENSMODG00000011119; Expressed in cerebellum and 15 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR45876; FI04035P; 1.
DR PANTHER; PTHR45876:SF1; RHO GTPASE-ACTIVATING PROTEIN 39; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002280}.
FT DOMAIN 44..78
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 696..848
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 863..1048
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 92..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 375..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..125
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..158
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..459
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..485
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1053 AA; 120804 MW; B885A24BA2B1BE5B CRC64;
FIWIFIFGLE WVEIIEPRTR ERMYANLITG ECVWDPPAGV RIKRTNENQW WELFDPNTSR
FYYYNATTQR TVWHRPQNCD IIPLAKLQTL KQNTESPRAS TENSPGRSSN VSREGSTSSS
LEQELETNEK AQEQQARVNR QSTQFTAVKE ENESSSPSGV FLEKDYEIYR DYNAEGQLLH
YRTSSLRWNT GTKERMLIKV TDREPSFLMH QGNDYPTDNQ PGPRSRRPSG GQQSPNLQTF
APDPDNSVFF PERKPSPFLK RAEHHSSESQ PSSPRYAYEP PLYEEPPMEY QAPIYDEPPI
DMQYDASGSY KAGSPQKSPI RKPHSFLQSP KQTSNSPYQQ LVLTKQKCTD RFMSLEYSPA
GKEYVRQLVY VEQSGSSPKL KTGLRHKYSP NPIGGSYSLQ HSPCLVRDQR LEIKSGDYSS
MEGSDFRHGQ PISQLPHGED SMSWSSQQDT MSSTGYSPGT RKRKSRKPSL SQDPNTSSTD
GSGDRDLLSE QLGSEDRPLS GPSRPQMSRT ESKSVEADMV RGFPEPFLAQ ARLAWEAQQA
HYHMKQRSSW DSQKDGSGYE SDGALPLPMP GPVVRAFSED EALAQQENKH WKRNTFEKLG
FPQILLEKSV SVQTNLASPE PYLHPSQSED LGACAQFESS RQNRNMMPSA SCVFPTFTLR
KPSSETDIEN WASKHFNKHT QGLFRRKVSI ANMLAWSSES IKKPMIMTSD RNVKKEACEI
FKLIQMYMGD RRAKGDQLSV ALEVATKGWS MQGLRDELYI QLCRQTTENF RYESLARGWE
LMAICLAFFP PTPKFHSYLE GYIYRHMDPV NDTKVTQHIK ELLERNTKKK SKLRKKPKPY
FEEHDGVAIS TYAKYCYNKL QKAALTGAKK VLVSFPCFNL ALLPRLVKRL TSWVKCFLER
SWVPGDIDEV NALKLQVDHW KIPTGLEDPH VPASLLKLWY RELEEPLIPH EFYEQCITHY
ENPEAAIAVV HSLPRINRMV LCYLIRFLQV FVQPANVAVT KMDVSNLAMV MAPNCLRCQS
DDPRIIFENT RKEMSFLRVL IQHLDTSFME GVL
//
