ID F7BEM5_HORSE Unreviewed; 420 AA.
AC F7BEM5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Mannose-1-phosphate guanyltransferase alpha {ECO:0000256|ARBA:ARBA00040222};
DE AltName: Full=GDP-mannose pyrophosphorylase A {ECO:0000256|ARBA:ARBA00042915};
DE AltName: Full=GTP-mannose-1-phosphate guanylyltransferase alpha {ECO:0000256|ARBA:ARBA00041992};
GN Name=GMPPA {ECO:0000313|Ensembl:ENSECAP00000009743.1,
GN ECO:0000313|VGNC:VGNC:18409};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000009743.1, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000009743.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000009743.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000009743.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000009743.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May serve as a regulatory subunit and allow allosteric
CC feedback inhibition of GMPPB by GDP-mannose.
CC {ECO:0000256|ARBA:ARBA00037787}.
CC -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC {ECO:0000256|ARBA:ARBA00007274}.
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DR RefSeq; XP_001492105.2; XM_001492055.5.
DR RefSeq; XP_005610689.1; XM_005610632.2.
DR RefSeq; XP_005610690.1; XM_005610633.2.
DR RefSeq; XP_005610691.1; XM_005610634.2.
DR AlphaFoldDB; F7BEM5; -.
DR SMR; F7BEM5; -.
DR STRING; 9796.ENSECAP00000009743; -.
DR PaxDb; 9796-ENSECAP00000009743; -.
DR Ensembl; ENSECAT00000012341.4; ENSECAP00000009743.1; ENSECAG00000011565.4.
DR GeneID; 100059471; -.
DR KEGG; ecb:100059471; -.
DR CTD; 29926; -.
DR VGNC; VGNC:18409; GMPPA.
DR GeneTree; ENSGT00940000157018; -.
DR HOGENOM; CLU_029499_3_0_1; -.
DR InParanoid; F7BEM5; -.
DR OMA; MPVPNWW; -.
DR OrthoDB; 5486038at2759; -.
DR TreeFam; TF300832; -.
DR Proteomes; UP000002281; Chromosome 6.
DR Bgee; ENSECAG00000011565; Expressed in synovial membrane of synovial joint and 23 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016740; F:transferase activity; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd06428; M1P_guanylylT_A_like_N; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR InterPro; IPR001451; Hexapep.
DR InterPro; IPR018357; Hexapep_transf_CS.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR22572:SF104; MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE ALPHA; 1.
DR PANTHER; PTHR22572; SUGAR-1-PHOSPHATE GUANYL TRANSFERASE; 1.
DR Pfam; PF00132; Hexapep; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:F7BEM5};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 3..194
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
SQ SEQUENCE 420 AA; 46075 MW; FA282AA0EBA89E9E CRC64;
MLKAVILIGG PQKGTRFRPL SFEVPKPLFP VAGVPMIQHH IEACAQVPGM QEILLIGFYQ
PDEALTRFLE AAQQEFHLPV RYLQEFAPLG TGGGLYHFRD QILAGGPEAF FVLNADVCSD
FPLSAMLDAH RHQPHPFLLL GTTANRTQSL NYGCIVENPQ THEVLHYVEK PSTFVSDVIN
CGIYLFSPEA LKPLGDVFQR NQQDGQLEDS SGLWRGAGTI RLEQDVFSAL AGQGQIYVYL
TEGIWSQIKS AGSALYASRL YLGQYQLTHP ERLAKHTPGG PRIRGNVYIH PTAKVAPSAV
LGPNVSIGEG VTVGEGVRLR ESIVLHGATL QEHTCVLHSI VGWGSTVGRW ARVEGTPNDP
NPNDPRAHMD SESLFKDGKL LPAITILGCR VRIPAEVLIL NSIVLPHKEL SRSFTNQIIL
//
