ID F7BGJ8_HORSE Unreviewed; 1320 AA.
AC F7BGJ8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Uromodulin like 1 {ECO:0000313|Ensembl:ENSECAP00000011750.3};
GN Name=UMODL1 {ECO:0000313|VGNC:VGNC:52452};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000011750.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000011750.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000011750.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000011750.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000011750.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSECAT00000014688.4; ENSECAP00000011750.3; ENSECAG00000013946.4.
DR VGNC; VGNC:52452; UMODL1.
DR GeneTree; ENSGT00940000159975; -.
DR HOGENOM; CLU_005456_0_0_1; -.
DR TreeFam; TF329882; -.
DR Proteomes; UP000002281; Chromosome 26.
DR Bgee; ENSECAG00000013946; Expressed in adult mammalian kidney and 5 other cell types or tissues.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0030414; F:peptidase inhibitor activity; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00199; WAP; 1.
DR Gene3D; 4.10.75.10; Elafin-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 2.60.40.4100; Zona pellucida, ZP-C domain; 1.
DR Gene3D; 2.60.40.3210; Zona pellucida, ZP-N domain; 1.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR036645; Elafin-like_sf.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR InterPro; IPR008197; WAP_dom.
DR InterPro; IPR042235; ZP-C.
DR InterPro; IPR001507; ZP_dom.
DR PANTHER; PTHR14002; ENDOGLIN/TGF-BETA RECEPTOR TYPE III; 1.
DR PANTHER; PTHR14002:SF22; UROMODULIN-LIKE 1; 1.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF01390; SEA; 1.
DR Pfam; PF00095; WAP; 1.
DR Pfam; PF00100; Zona_pellucida; 1.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00217; WAP; 1.
DR SMART; SM00241; ZP; 1.
DR SUPFAM; SSF57256; Elafin-like; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF82671; SEA domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS51041; EMI; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50024; SEA; 2.
DR PROSITE; PS51390; WAP; 1.
DR PROSITE; PS51034; ZP_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1320
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023826514"
FT TRANSMEM 1272..1295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..106
FT /note="EMI"
FT /evidence="ECO:0000259|PROSITE:PS51041"
FT DOMAIN 114..158
FT /note="WAP"
FT /evidence="ECO:0000259|PROSITE:PS51390"
FT DOMAIN 396..510
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 507..552
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 707..793
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 790..902
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 899..944
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 994..1237
FT /note="ZP"
FT /evidence="ECO:0000259|PROSITE:PS51034"
FT REGION 543..570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 643..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 938..978
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 598..630
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 659..684
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1320 AA; 142957 MW; 1F1871330A78989A CRC64;
MLRTLGLALL ALVSAVGPSQ ASGFTEKGLS LLSYQLCNYS VTQNVQKVEA VQTSHLTYVP
CGGWIPWRRC PKTVYRTRYL AVEVPEPRNV TDCCKGYEQL GLYCVLPLNR SQEFASRPGV
CPTVGLEAPS SLCTLDADCP GLQKCCPSSR GHHCVSPMPP AAERSPASFW YNVSVLVKMD
FEELQQVDPR LLNHMRLLHS MVTSALWPMD SAVHHLRSAG GDTSTTVSWL LLGLPRPVPV
ANVSAMLDGI VKRLYEVISI QVQDTNECFY DELNACSGRE LCLNVEGSYQ CLCHPESPTS
SPQRLNHTCE DCPPIRDHMT LNVTSSSFHV SWSLSSPQSH TFHVQVYKGE ELLRSARTRG
TTLEVAGLEA GVLYRVKTSY QRCGAHVTAA LTVRTDAQVF QVTVRILDRN VTEKLLDRGS
PEYQDFSRQL LHEVENSFPP AVSDLHRSGK LRVQIVSLQA GSVVVKLRLT VQDPEFPVGV
STLATMLPPL LASTVFQIDQ QGTLVQDWDE CADSLEHDCS PAAQCINLEG SYTCRCRTAR
DANPSRAGRA CEGDVVSPTG GTLSPATGVT APALGTETTA LGLETPTLSP SPRPPWGTPA
ASQAQTPGTP PRRAGSSVVE QDRNSTGQGV EELWRNSTME SSFWATPTEG PTGHVVWDTS
LPTRDTSPAP LDPTQPQNSD PGPSGSPDLP LAPSPTSLKT PACVPIPIRG VTVSNVTSTG
FHLAWAADLA LHPAFQLTLT STRSPTVHLE TRDASLTLSG LEPGVLHLVE IVAKACETES
ARARLKVRTA AQKLSGTVRI ANVEYVESFR NVSSREYQDF LELFFRTVRS SLPATMRRHL
DSGGVQVEVT SITNGSVVVE FNLLLLADVD VREVSAAFLT AFQNASVLEV VRGDTFIWDY
DECDAGEDDC VPGTSCRNTL GSFTCSCSGG APDFPVEYSG RPCEDDPPGN TTQVPGPEQP
PTPAGTGAAS VPGASVSPQG LPQRLNLTGA VRVLCEIEKV AIAVQRRFLQ QESIPESSLY
LGHPSCNVSD GNSTHVLLVA GWSECGTVVQ SNMTNTVVRT TLRNDLSPEG IIHHLKILSP
IHCAFQNDLL TSSGYTPEWG VYTIIEDLHG AGNFVTEMQL FIGDSPIPQN YSVSASDDVK
IEVGLYKQKS DLKVVLTECW ATPSSNARDP IMFGFINNSC PIPNTHTDVI ENGNSTKAQF
KLKIFSFVNN AIVYLHCKLR ICMESPGTTC KITCNDFRSL RSAESSGTHL MSWGPLIRTT
GESPGVEPGL GAGYLVLIVV AVFALVTGAA ALLVVRYQRM TGKYNFRTQS DNFSYQVFSE
//
