ID F7BIL4_HORSE Unreviewed; 1740 AA.
AC F7BIL4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
GN Name=ITGB4 {ECO:0000313|Ensembl:ENSECAP00000009107.2,
GN ECO:0000313|VGNC:VGNC:19178};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000009107.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000009107.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000009107.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000009107.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000009107.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU000633}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the integrin beta chain family.
CC {ECO:0000256|ARBA:ARBA00007449, ECO:0000256|RuleBase:RU000633}.
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DR STRING; 9796.ENSECAP00000009107; -.
DR PaxDb; 9796-ENSECAP00000009107; -.
DR Ensembl; ENSECAT00000011628.4; ENSECAP00000009107.2; ENSECAG00000010178.4.
DR VGNC; VGNC:19178; ITGB4.
DR GeneTree; ENSGT01100000263555; -.
DR InParanoid; F7BIL4; -.
DR OMA; HTKFRQQ; -.
DR TreeFam; TF105392; -.
DR Proteomes; UP000002281; Chromosome 11.
DR Bgee; ENSECAG00000010178; Expressed in oviduct epithelium and 20 other cell types or tissues.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005925; C:focal adhesion; IBA:GO_Central.
DR GO; GO:0008305; C:integrin complex; IBA:GO_Central.
DR GO; GO:0005178; F:integrin binding; IBA:GO_Central.
DR GO; GO:0048870; P:cell motility; IEA:InterPro.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR GO; GO:0031581; P:hemidesmosome assembly; IEA:InterPro.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IBA:GO_Central.
DR CDD; cd00063; FN3; 4.
DR Gene3D; 2.60.40.2030; -; 1.
DR Gene3D; 4.10.1240.30; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR040622; I-EGF_1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR033760; Integrin_beta_N.
DR InterPro; IPR015812; Integrin_bsu.
DR InterPro; IPR012013; Integrin_bsu-4.
DR InterPro; IPR012896; Integrin_bsu_tail.
DR InterPro; IPR036349; Integrin_bsu_tail_dom_sf.
DR InterPro; IPR002369; Integrin_bsu_VWA.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10082; INTEGRIN BETA SUBUNIT; 1.
DR PANTHER; PTHR10082:SF42; INTEGRIN BETA-4; 1.
DR Pfam; PF03160; Calx-beta; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF00041; fn3; 4.
DR Pfam; PF18372; I-EGF_1; 1.
DR Pfam; PF07965; Integrin_B_tail; 1.
DR Pfam; PF00362; Integrin_beta; 1.
DR Pfam; PF17205; PSI_integrin; 1.
DR PIRSF; PIRSF002513; Integrin_B4; 2.
DR PRINTS; PR00014; FNTYPEIII.
DR PRINTS; PR01186; INTEGRINB.
DR SMART; SM00237; Calx_beta; 1.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00187; INB; 1.
DR SMART; SM01242; Integrin_B_tail; 1.
DR SUPFAM; SSF141072; CalX-like; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF69687; Integrin beta tail domain; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS00243; INTEGRIN_BETA; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|RuleBase:RU000633};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU000633};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000633};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..1740
FT /note="Integrin beta"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040207333"
FT TRANSMEM 712..734
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1211..1310
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1448..1543
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1561..1657
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1113..1141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1740 AA; 193752 MW; 469281FD68D49D9F CRC64;
MAGPHPSPWT RLLLAALLSV SFPGDMANRC KKAQVKSCTE CIRVDKDCAY CTDEMFKERR
CNTQAELLAA GCRLESVVVM ERSFEITEAT QIDTTLRRSQ VSPQAMRVRL RPGEEQLFEL
EVFEPLESPV DLYILMDFSN SMSDDLDNLK KMGQNLARVL SQLTSDYTIG FGKFVDKVSV
PQTDMRPEKL KEPWPNSDPP FSFKNVISLT EDVNEFRSKL QGERISGNLD APEGGFDAIL
QTAVCTRDIG WRPDSTHLLV FSTESAFHYE ADGANVLAGI MSRNDEECHL DATGTYTQYK
TQDYPSVPTL VRLLGKHNII PIFAVTNYSY SYYEKLHTYF PVSSLGVLQE DSSNIVELLE
EAFNRIRSNL DIRALESPRG LKTEITSKVF QKTKTGSFHI RRGEVGTYYV QLRAIEDVDG
THVCQLPLED QKGNIHLKPS FSDGLRIDVG VICDVCSCEL QKEVRSAHCS FNGDFMCGHC
MCNEGWSGKT CNCSTGSLSD TQPCLREDED KPCSGRGECQ CGRCVCYGEG RYEGQFCEYD
NFQCPRTSGF LCNDRGRCSM GQCVCEPGWT GSSCDCPLSN ATCIDSNGGI CNGRGHCECG
RCHCNQQSLY TDTICEINYS AIRLGLCEDL RSCVQCQAWG TGEKKGRTCE ECSFKVKMVD
KLKKAEEVVE YCSFRDEDDD CTYSYTVEGD GAPGPNSTVL VHRKKDCPPT SFWWLIPLLI
FLLLLLALLL LLCWKYCACC KACLALLPCC NRGHMVGFKE DHYMLRENLM ASDHLDTPML
RSGNLKGRDT VRWKITNNVQ RPGFATRVAS TNPTELVPYG LSLRLARLCT ENLLKPDTRE
CNQLRQEVEE NLNEVYRQIT GAYKLQQTKF RQQPNAGKKQ DHTIVDTVLM APRSAKQTLL
KLTEKHVEQG AFHELKVAPG YYTLTADQDA RGMVEFQEGV ELVDVRVPLF IRPEDDDEKQ
LLVEAIDVPV GTATLGRRLV NITIIKEQAS GIVSFEQPEY LVSGGEQVAR IPVVRRILDN
GKSQVSYRTQ DNTAQGNRDY IPVEGELLFQ PGEMWKELQV KLLELQEMDS LLRGRQTRHF
HIQLSNPKFG ARLGQPHSAT VIIGDPDELD RNLISQTVSS PPPPRGDLGA PQNPNAKAAG
SRKIHFNWLP PPGKPTGYRV KYWIQGDSEL EAHLLDSKVP SVELTNLYPY CDYEMKVSLV
SCRTHQEVPS EPGRLAFNVV SSTVTQLSWA EPAETNGEIT AYEVCYGLVN EDNRPIGPMK
KVLVDSPKKR TLLIENLRES QPYRYTVKAR NGAGWGPERE AIINLATQPK RPMSIPIIPD
IPIVDAQSGE DYESFLMYSD DVLRSPAGSQ RPSVSDDTEH LVNGRMDFAY PGSANSLHRM
TVANAAYGTH LSPHLPHRVL STSSTLTRDY HSLTRTEHSH TATLPRDYST LTSLSSHSSR
LAAGVPNTPT RLVFSALGPT SLKVSWQEPQ CDQALQGYSV EYQLLNGGEL HRLNIPNPSQ
TSVVVEDLLP NHSYVFRVRA QSQEGWGPER EGVITIESQV HPQSPLCPLP GSTFTLSTPS
APGPLVFTAL SPDSLQLSWE RPRRPDGDIL GYLVTCEMAH GGEPATTFLV DGDSPESRLT
VPGLSENVPY KFKVQAKTTQ GFGPEREGII TIESQDGGPF PQLGSHSGLF QHPLPGEYSS
ITTTHTSTIE PFLLDGLTLG SQHLEAGGSL TRHVTQEFVS RTLTTSGTLS TQVDQQFFQT
//
