ID F7BZ71_HORSE Unreviewed; 423 AA.
AC F7BZ71;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Hydroxylysine kinase {ECO:0000256|ARBA:ARBA00040505};
DE EC=2.7.1.81 {ECO:0000256|ARBA:ARBA00038873};
GN Name=HYKK {ECO:0000313|Ensembl:ENSECAP00000005619.2,
GN ECO:0000313|VGNC:VGNC:18919};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000005619.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000005619.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000005619.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000005619.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000005619.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-
CC lysine. {ECO:0000256|ARBA:ARBA00037368}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(5R)-5-hydroxy-L-lysine + GTP = (5R)-5-phosphooxy-L-lysine +
CC GDP + H(+); Xref=Rhea:RHEA:19049, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:37565, ChEBI:CHEBI:57882, ChEBI:CHEBI:58189,
CC ChEBI:CHEBI:58357; EC=2.7.1.81;
CC Evidence={ECO:0000256|ARBA:ARBA00036820};
CC -!- SIMILARITY: Belongs to the aminoglycoside phosphotransferase family.
CC {ECO:0000256|ARBA:ARBA00006219}.
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DR RefSeq; XP_005602936.2; XM_005602879.2.
DR AlphaFoldDB; F7BZ71; -.
DR STRING; 9796.ENSECAP00000005619; -.
DR PaxDb; 9796-ENSECAP00000005619; -.
DR Ensembl; ENSECAT00000007647.3; ENSECAP00000005619.2; ENSECAG00000007552.3.
DR GeneID; 100060343; -.
DR CTD; 123688; -.
DR VGNC; VGNC:18919; HYKK.
DR GeneTree; ENSGT00390000011314; -.
DR HOGENOM; CLU_042971_1_1_1; -.
DR InParanoid; F7BZ71; -.
DR OMA; AAHSCQL; -.
DR OrthoDB; 5398335at2759; -.
DR TreeFam; TF324471; -.
DR Proteomes; UP000002281; Chromosome 1.
DR Bgee; ENSECAG00000007552; Expressed in adult mammalian kidney and 23 other cell types or tissues.
DR ExpressionAtlas; F7BZ71; baseline.
DR GO; GO:0019202; F:amino acid kinase activity; IBA:GO_Central.
DR GO; GO:0047992; F:hydroxylysine kinase activity; IEA:Ensembl.
DR Gene3D; 3.90.1200.10; -; 1.
DR InterPro; IPR002575; Aminoglycoside_PTrfase.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR PANTHER; PTHR21064:SF1; HYDROXYLYSINE KINASE; 1.
DR PANTHER; PTHR21064; UNCHARACTERIZED; 1.
DR Pfam; PF01636; APH; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 104..327
FT /note="Aminoglycoside phosphotransferase"
FT /evidence="ECO:0000259|Pfam:PF01636"
SQ SEQUENCE 423 AA; 47281 MW; 0E0EF3E1E41560DD CRC64;
MGGPGCRGSG ATFQCQRCAV AGVQGCCRAG SKSGRSLRIC LFPLDIMSSG DDQQSQALAK
PTFSEVQASA LVESVFGLKV FKIQPLPSYD DQNFHVCISR TKDTTDGPTE YVLKISNTKS
SKTPDLIEVQ SHIIMFLRAA GFPTASVCRT KGDNITSLMS VDSGSEIKNY LVRLLTYLPG
RPIAEIPISP QLLYEIGRLA AKLDKTLEKF HHPKLSSLHR ENFIWNLKNV PLLEKYLYAL
GQNRNREIVK QIIQLFKDEV MSKLSHFREC INHGDLNDHN ILIESSKSAF GDAVYQVSGI
LDFDDMSYGY YAFELAITIM YMMIESKNPI QVGGHVLAGF ESIIPLTTVE RSALFLLVCS
RFCQSLVMAA YSCQLHPENE EYLMITAKTG WKHLQQMFDM GQKTVEEIWF ETAKSYKSGI
PCD
//
