ID F7C507_ORNAN Unreviewed; 570 AA.
AC F7C507;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=2-hydroxyacyl-CoA lyase 1 {ECO:0000313|Ensembl:ENSOANP00000010773.3};
GN Name=HACL1 {ECO:0000313|Ensembl:ENSOANP00000010773.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000010773.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000010773.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000010773.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-hydroxyoctadecanoyl-CoA = formyl-CoA + heptadecanal;
CC Xref=Rhea:RHEA:55196, ChEBI:CHEBI:57376, ChEBI:CHEBI:74116,
CC ChEBI:CHEBI:138631; Evidence={ECO:0000256|ARBA:ARBA00000194};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55197;
CC Evidence={ECO:0000256|ARBA:ARBA00000194};
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
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DR AlphaFoldDB; F7C507; -.
DR STRING; 9258.ENSOANP00000010773; -.
DR Ensembl; ENSOANT00000010775.3; ENSOANP00000010773.3; ENSOANG00000006750.4.
DR eggNOG; KOG1185; Eukaryota.
DR GeneTree; ENSGT00940000156802; -.
DR HOGENOM; CLU_013748_3_3_1; -.
DR InParanoid; F7C507; -.
DR OMA; YMGMIGM; -.
DR OrthoDB; 1966690at2759; -.
DR TreeFam; TF105690; -.
DR Proteomes; UP000002279; Unplaced.
DR Bgee; ENSOANG00000006750; Expressed in liver and 8 other cell types or tissues.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005777; C:peroxisome; IBA:GO_Central.
DR GO; GO:0106359; F:2-hydroxyacyl-CoA lyase activity; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0000287; F:magnesium ion binding; IEA:Ensembl.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IBA:GO_Central.
DR GO; GO:0001561; P:fatty acid alpha-oxidation; IBA:GO_Central.
DR GO; GO:1903512; P:phytanic acid metabolic process; IEA:Ensembl.
DR GO; GO:0006625; P:protein targeting to peroxisome; IEA:Ensembl.
DR CDD; cd02004; TPP_BZL_OCoD_HPCL; 1.
DR CDD; cd07035; TPP_PYR_POX_like; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR045025; HACL1-like.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR PANTHER; PTHR43710; 2-HYDROXYACYL-COA LYASE; 1.
DR PANTHER; PTHR43710:SF2; 2-HYDROXYACYL-COA LYASE 1; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 7..120
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 195..324
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 393..549
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 570 AA; 62362 MW; 6B7CF11953B9C960 CRC64;
MAEERLSGAK VVALALKAQK VEYVFGIVGI PVTEIAIAAQ EVGIKYLGMR NEQAACYAAS
AVGYLTGRPG VCLVVSGPGL IHALGGMANA NMNCWPVIVI GGSSDRNQET MGAFQEFPQV
EACRLYSKFS ARPSSVEVIP SVIEKAVRNS IYGRPGACYV DIPGDFVNHY VAVSSIKYVE
CCLPPPISMA DASAISEAAT IIRNAKRPLL IIGKGAAYAC AEENIRKFVE QCGLPFLPTP
MGKGVVPDNH PNCVAAARSR ALQHADVIIL LGARLNWILH FGLPPRYQPD VKIIQVDICA
EELGNNVRPV AALLGDLNAV TEQLLDYFEK RPWKYPPNTE WWKTLKEKKK SNEELSKKLA
SQVSLPMNYY TVFHHIQQQL PKDCIIVSEG ANTMDIGRTV LQNCLPRHRL DAGTFGTMGV
GLGFAIAAAV VTRDRNPEQK VICVEGDSAF GFSGMEVETI CRYNLPILII VVNNNGIYQG
FDANTWKEIL KLGDTTIVAP PVSLLPNSHY EQVMTAFGGK GYFVQTPQEL QNALRAGLKE
KTMPSLINVM IEPQASRKEQ DFHWLTRSNM
//
