ID F7C5C0_CALJA Unreviewed; 401 AA.
AC F7C5C0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=ERCC excision repair 8, CSA ubiquitin ligase complex subunit {ECO:0000313|Ensembl:ENSCJAP00000028308.3};
GN Name=ERCC8 {ECO:0000313|Ensembl:ENSCJAP00000028308.3};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000028308.3, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000028308.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000028308.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F7C5C0; -.
DR STRING; 9483.ENSCJAP00000028308; -.
DR Ensembl; ENSCJAT00000029914.5; ENSCJAP00000028308.3; ENSCJAG00000015351.5.
DR eggNOG; KOG4283; Eukaryota.
DR GeneTree; ENSGT00390000009065; -.
DR InParanoid; F7C5C0; -.
DR OMA; CMTAVKA; -.
DR TreeFam; TF101237; -.
DR Proteomes; UP000008225; Chromosome 2.
DR Bgee; ENSCJAG00000015351; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0031464; C:Cul4A-RING E3 ubiquitin ligase complex; IEA:Ensembl.
DR GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR GO; GO:0000109; C:nucleotide-excision repair complex; IEA:Ensembl.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:Ensembl.
DR GO; GO:0097680; P:double-strand break repair via classical nonhomologous end joining; IEA:Ensembl.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0051865; P:protein autoubiquitination; IEA:Ensembl.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:Ensembl.
DR GO; GO:0090262; P:regulation of transcription-coupled nucleotide-excision repair; IEA:Ensembl.
DR GO; GO:0006979; P:response to oxidative stress; IEA:Ensembl.
DR GO; GO:0009411; P:response to UV; IEA:Ensembl.
DR GO; GO:0010165; P:response to X-ray; IEA:Ensembl.
DR GO; GO:0000012; P:single strand break repair; IEA:Ensembl.
DR GO; GO:0006283; P:transcription-coupled nucleotide-excision repair; IEA:Ensembl.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR042238; Rad28/ERCC8/Ckn1/ATCSA-1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR46202; DNA EXCISION REPAIR PROTEIN ERCC-8; 1.
DR PANTHER; PTHR46202:SF1; DNA EXCISION REPAIR PROTEIN ERCC-8; 1.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 45..87
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 101..143
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 188..223
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 247..288
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 376..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 401 AA; 44462 MW; 9AEE7C70FDBC75ED CRC64;
MIARDASKLQ VLGSLLISAS QSARTTGRHE PLVLGLELNK DRDVERIHGG GINTLDIEPV
EGRYMLSGGS DGVIVLYDLE NSSRQPYYTC KAVCSVDRYH PDVHKYSVET VQWYPHDTGM
FTSSSFDKTL KVWDTNTLQT ADVFNFEETV YSHHMSPVST KHCLVAVGTR GPKVQLCDLK
SGSCSHILQG HRQEILAVSW SPRYDYILAT ASADSRVKLW DVRRASGCLI TLDQHNGEKS
QAVESANTAH NGKVNGLCFT SDGLHLLTVG TDNRMRLWNS FNGENTLVNY GKVCNNSKKG
LKFTVSCGCS SEFVFVPYGS TVAVYTVYSG EQITMLKGHY KSVDCCVFQS HFQELYSGSR
DCNILAWVPS LYEPVPDDDE TTKSQLNPAF EDAWSSSDEE G
//
