ID F7CC05_XENTR Unreviewed; 997 AA.
AC F7CC05;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=GRB10 interacting GYF protein 1 {ECO:0000313|Ensembl:ENSXETP00000054059};
DE SubName: Full=GRB10-interacting GYF protein 1 isoform X1 {ECO:0000313|RefSeq:XP_031753932.1};
GN Name=gigyf1 {ECO:0000313|Ensembl:ENSXETP00000054059,
GN ECO:0000313|RefSeq:XP_031753932.1,
GN ECO:0000313|Xenbase:XB-GENE-5911708};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000054059};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000054059}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000054059};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000054059}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_031753932.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_031753932.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_031753932.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GIGYF family.
CC {ECO:0000256|ARBA:ARBA00038015}.
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DR RefSeq; XP_031753932.1; XM_031898072.1.
DR Ensembl; ENSXETT00000054059; ENSXETP00000054059; ENSXETG00000018415.
DR AGR; Xenbase:XB-GENE-5911708; -.
DR Xenbase; XB-GENE-5911708; gigyf1.
DR eggNOG; KOG1862; Eukaryota.
DR OMA; FHNTGEC; -.
DR OrthoDB; 5406906at2759; -.
DR TreeFam; TF325513; -.
DR Proteomes; UP000008143; Chromosome 3.
DR Bgee; ENSXETG00000018415; Expressed in 4-cell stage embryo and 12 other cell types or tissues.
DR CDD; cd00072; GYF; 1.
DR Gene3D; 3.30.1490.40; -; 1.
DR InterPro; IPR003169; GYF.
DR InterPro; IPR035445; GYF-like_dom_sf.
DR PANTHER; PTHR14445; GRB10 INTERACTING GYF PROTEIN; 1.
DR PANTHER; PTHR14445:SF37; GRB10-INTERACTING GYF PROTEIN 1; 1.
DR Pfam; PF02213; GYF; 1.
DR SMART; SM00444; GYF; 1.
DR SUPFAM; SSF55277; GYF domain; 1.
DR PROSITE; PS50829; GYF; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT DOMAIN 486..534
FT /note="GYF"
FT /evidence="ECO:0000259|PROSITE:PS50829"
FT REGION 105..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 182..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 318..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 767..792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 815..845
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 941..962
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..165
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..226
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..260
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..336
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 770..792
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 823..840
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 941..961
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 997 AA; 111578 MW; 6AC479A0D88CC2F3 CRC64;
MAAETLNFGP EWLRALSSGG SVASPPPSPA MPKYKLAEYR YGREEMLALY IKENKVPEEM
QDKEFAVILN EEPLQPLALL PLTEEEQRNF SLSVNSVPVL RLMGKGAAPP TSGAARGRGT
ARGRGRGRGD SALYPRTLDD QDPGFSRGGR EIHRSQSWDD RGERRFEKPI RREAVRVGFE
EPAAPSRKEF ARSDSDNWRT LREGQEEDED GNWRLAVTRR DERWRSTSPG ANSGESPRSA
GWRDHGERRR KFDFEMVREE SGSAPRSGGR SGDGHDDERD GLPEWCMEDE DDEMGTFDSS
GAFLSFKKSP KETILEEQEL EFQGVEEEES KEEGAERLED EDSSVPHEDA VPDVVPTPSE
PPNLIWGGAL YADEEGDRCP EVPPADGEEA VQGEKQQGPG EEGDPGTFIP PSLSPLATLP
PPSSSPPVAA TEFSVGDPEE DEGMKHLQQE AEKLVASLQD SSLEEDGFSS ARSHSAAALP
LSHEAAMKWF YKDPQGEIQG PFTTQEMAEW CQAGYFTMSL LVKRGCDEGF QPLGEVIKMW
GRVPFAPGPS PPPLLSNIDQ QCLKKQQELA LYQQLQHQYL LQLINRQQYP QKSGDLTPQQ
QQQLALFLQQ LNPSKSRTSE AALLPSMNRS LSVPDTGSLW DLHTSATQTS GGDPALWDLP
ATAASQGPTL EQQLQLHQKL QERRDAELRA KREEEERKRR EEKRRQEEQK RREEEEIYRR
KQQCRQQQEL LLKLLQQSGQ PSPPAVWGSH GKGLSLKAML EMQEREGQLL KQRGQPSRQG
HGGLGLTNAS VLPSQWGADS GSLWGGPDKS LWDDGVKSGA GSRGLRNSRS SPSLTDTYAA
SARRKKTEEE EKLLKLLQGF KPSDGFTQWC EQMLHILNTS NNLDVPTLVA ILKELESPYD
VHDYIRSCLG ETLEAKEFAK QFLERRAKYK ASQRQQVQES AWLTPSMFPS SQNSKPSAYD
TQSNKMKRRI HMLHSDPSIL GYSLHGSPNE MEAIDDY
//
