ID F7CPF4_XENTR Unreviewed; 256 AA.
AC F7CPF4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Homeobox protein MSX-2 {ECO:0000313|RefSeq:XP_002936749.1};
DE SubName: Full=Msh homeobox 2 {ECO:0000313|Ensembl:ENSXETP00000020130};
GN Name=msx2 {ECO:0000313|Ensembl:ENSXETP00000020130,
GN ECO:0000313|RefSeq:XP_002936749.1,
GN ECO:0000313|Xenbase:XB-GENE-852974};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000020130};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000020130}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000020130};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000020130}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_002936749.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_002936749.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_002936749.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the Msh homeobox family.
CC {ECO:0000256|ARBA:ARBA00038425}.
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DR RefSeq; XP_002936749.1; XM_002936703.5.
DR Ensembl; ENSXETT00000020130; ENSXETP00000020130; ENSXETG00000009168.
DR GeneID; 394987; -.
DR KEGG; xtr:394987; -.
DR AGR; Xenbase:XB-GENE-852974; -.
DR CTD; 4488; -.
DR Xenbase; XB-GENE-852974; msx2.
DR eggNOG; KOG0492; Eukaryota.
DR HOGENOM; CLU_072675_1_0_1; -.
DR OMA; PVGYNMY; -.
DR OrthoDB; 4848801at2759; -.
DR TreeFam; TF350699; -.
DR Proteomes; UP000008143; Chromosome 3.
DR Bgee; ENSXETG00000009168; Expressed in neurula embryo and 7 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR24338; HOMEOBOX PROTEIN MSX; 1.
DR PANTHER; PTHR24338:SF10; HOMEOBOX PROTEIN MSX-2; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT DOMAIN 129..189
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 131..190
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 47..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 256 AA; 28428 MW; 19C0C0998FC9C08B CRC64;
MSSPRKIKED LSSDEEGQVH PTLSPSDDHK IKVSSLPFSV EALMADKRVP KEAPHLRGVD
ASAAGSTPRH LHMGIRDSPS PPGLTKTFET SSVKSENSED GTTWSKDGGS YSPPPRHLSP
STCTLRKHKT NRKPRTPFTT SQLLALERKF RQKQYLSIAE RAEFSSSLNL TETQVKIWFQ
NRRAKAKRLQ EAEIEKLKMA AKPILPPGFS IPFPINSPIQ AASLYGSSYQ FHRPVLPIPP
VGLYATPVGY SMYHLS
//
