ID F7D736_ORNAN Unreviewed; 484 AA.
AC F7D736;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Angiopoietin like 2 {ECO:0000313|Ensembl:ENSOANP00000017443.3};
GN Name=ANGPTL2 {ECO:0000313|Ensembl:ENSOANP00000017443.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000017443.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000017443.3, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000017443.3,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000017443.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000017443.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_001515613.1; XM_001515563.3.
DR RefSeq; XP_003428437.1; XM_003428389.2.
DR AlphaFoldDB; F7D736; -.
DR STRING; 9258.ENSOANP00000017443; -.
DR Ensembl; ENSOANT00000017446.4; ENSOANP00000017443.3; ENSOANG00000011011.5.
DR GeneID; 100085245; -.
DR KEGG; oaa:100085245; -.
DR CTD; 23452; -.
DR eggNOG; KOG2579; Eukaryota.
DR GeneTree; ENSGT00940000155946; -.
DR HOGENOM; CLU_038628_0_0_1; -.
DR InParanoid; F7D736; -.
DR OMA; CVTYWWL; -.
DR OrthoDB; 3134470at2759; -.
DR TreeFam; TF336658; -.
DR Proteomes; UP000002279; Chromosome 4.
DR Bgee; ENSOANG00000011011; Expressed in fibroblast and 7 other cell types or tissues.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR CDD; cd00087; FReD; 1.
DR Gene3D; 3.90.215.10; Gamma Fibrinogen, chain A, domain 1; 1.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR020837; Fibrinogen_CS.
DR NCBIfam; NF040941; GGGWT_bact; 1.
DR PANTHER; PTHR19143:SF24; ANGIOPOIETIN-RELATED PROTEIN 2; 1.
DR PANTHER; PTHR19143; FIBRINOGEN/TENASCIN/ANGIOPOEITIN; 1.
DR Pfam; PF00147; Fibrinogen_C; 1.
DR SMART; SM00186; FBG; 1.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR PROSITE; PS00514; FIBRINOGEN_C_1; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..484
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5028264264"
FT DOMAIN 260..480
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
FT COILED 74..101
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 484 AA; 56100 MW; 810D0048531222A0 CRC64;
MQTVRLTCLV LIAAVGVAAQ SSDEEKEQEF VYLNRYKRSS DPPDKCTYTF VVPQQKVTGA
ICVNSKEPDV LLENRVHKQE LELLNNELLK QKRQIETLQQ LVEVDGGIVN EVKLLRKESR
NMNSRVTQLY MQLLHEIIRK RDNALELSQL ENKILNQTAD VLQLANRYKD LEHKYQHLAS
LANNQSAIIA QLEEHCQRMP TVRPIPPPPQ PPNRVYQPPT YNRIINQIST NEIQSDQNLK
VLPPPLPTMP TVTSIPTSTD KPSGPWRDCL QALEDGHDTS SIYLVKPDNA NRLMQVWCDQ
RHDPGGWTVI QRRLDGSVNF FRNWETYKQG FGNIDGEYWL GLENIYWLTN QGNYKLLVTM
EDWTGRKVFA EYASFRLEPE SEYYKLRLGR YNGNAGDSFT WHNGKQFTTL DRDHDVYAGN
CAHYQKGGWW YNACAHSNLN GVWYRGGHYR SRYQDGVYWA EFRGGSYSLK KVVMMIRPNP
NTFH
//
