ID F7DH21_XENTR Unreviewed; 577 AA.
AC F7DH21;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Solute carrier family 39 (zinc transporter), member 5 {ECO:0000313|Ensembl:ENSXETP00000020957};
GN Name=slc39a5 {ECO:0000313|Ensembl:ENSXETP00000020957};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000020957};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000020957}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000020957};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000020957}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000256|ARBA:ARBA00006939}.
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DR AlphaFoldDB; F7DH21; -.
DR STRING; 8364.ENSXETP00000020957; -.
DR PaxDb; 8364-ENSXETP00000017331; -.
DR Ensembl; ENSXETT00000020957; ENSXETP00000020957; ENSXETG00000009499.
DR AGR; Xenbase:XB-GENE-952069; -.
DR Xenbase; XB-GENE-952069; slc39a5.
DR eggNOG; KOG2693; Eukaryota.
DR HOGENOM; CLU_015114_13_2_1; -.
DR TreeFam; TF318470; -.
DR Bgee; ENSXETG00000009499; Expressed in neurula embryo and 5 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR003689; ZIP.
DR PANTHER; PTHR12191; SOLUTE CARRIER FAMILY 39; 1.
DR PANTHER; PTHR12191:SF17; ZINC TRANSPORTER ZIP5; 1.
DR Pfam; PF02535; Zip; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 237..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 482..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 510..527
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 548..568
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 131..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 577 AA; 63517 MW; F4F439C0442F8265 CRC64;
MQALLTRTLH DKEDSLSLED AEKEQGYYLQ QLFHLYGEND TLTYEGLTLL LQNLGLGKVQ
VVEIEHTDLG HDHVSHLDIL DVQGNKHSHM HSSREHLQSS TTMPLPVIQT KNARSVEVNS
GITRPVHAVS LKSTQMPPHN GKRGSTQPGQ NQRPTEDILK RVIQLHHSQF SHQHENCLNV
TQLLMNFGLS WVSAITPQQF SLLCPALLYQ IDSRVCIHHS DELTNSKPDS KQALLQVLGW
GALAVTVISA PSLLAVAFVP LLRRPLFRYL LRFLVALAVG TLCGDALLHL MPHAQEDHTG
NQHGGKTHAI EPVLKGLSVL GGLYLLFLIE NLMGLLKQRQ QLKRLSKPEV PAGDESYTTA
LWDLGSPVES EFCEVSRAAE ILQRGNEEVA IRRRDEKDAP APHSHSGHSH NMASKGITEI
VWMVLLGDGI HNFTDGLAIG AAFSSGFSGG LSTTVAVFCH ELPHELGDFA VLLQSGVPVR
KVLFFSLVSA FLSFFGMIIG AVASQNSAQI TPWIFAATAG IFLYVALVDM LPQMLHRETA
DPCQGKDCVI HSLGFLLGCA IMFCIALYQD QMVFLDL
//
