ID F7DHF7_HORSE Unreviewed; 738 AA.
AC F7DHF7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=RNA polymerase II-associated protein 3 {ECO:0000256|ARBA:ARBA00040133};
GN Name=RPAP3 {ECO:0000313|VGNC:VGNC:22514};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000017723.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000017723.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017723.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000017723.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017723.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RPAP3 family.
CC {ECO:0000256|ARBA:ARBA00038275}.
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DR AlphaFoldDB; F7DHF7; -.
DR STRING; 9796.ENSECAP00000017723; -.
DR PaxDb; 9796-ENSECAP00000017723; -.
DR Ensembl; ENSECAT00000021515.3; ENSECAP00000017723.3; ENSECAG00000020050.4.
DR VGNC; VGNC:22514; RPAP3.
DR GeneTree; ENSGT00940000156749; -.
DR HOGENOM; CLU_023272_1_0_1; -.
DR InParanoid; F7DHF7; -.
DR OMA; NFTPDRP; -.
DR Proteomes; UP000002281; Chromosome 6.
DR Bgee; ENSECAG00000020050; Expressed in brainstem and 23 other cell types or tissues.
DR ExpressionAtlas; F7DHF7; baseline.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0101031; C:protein folding chaperone complex; IBA:GO_Central.
DR GO; GO:0097255; C:R2TP complex; IEA:Ensembl.
DR GO; GO:1990062; C:RPAP3/R2TP/prefoldin-like complex; IEA:Ensembl.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR025986; RPAP3-like_C.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR46423; RNA POLYMERASE II-ASSOCIATED PROTEIN 3; 1.
DR PANTHER; PTHR46423:SF1; RNA POLYMERASE II-ASSOCIATED PROTEIN 3; 1.
DR Pfam; PF13877; RPAP3_C; 1.
DR Pfam; PF00515; TPR_1; 2.
DR Pfam; PF13432; TPR_16; 1.
DR SMART; SM00028; TPR; 6.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 3.
DR PROSITE; PS50293; TPR_REGION; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 133..166
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 201..234
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 349..382
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 545..635
FT /note="RNA-polymerase II-associated protein 3-like C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF13877"
FT REGION 37..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 106..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 738 AA; 83911 MW; 52B88958A218DEB5 CRC64;
MTSTNKAIEL QLQVKQNAEE LQDFMRDLEN WEKDIKQKDM ELRRQSGVPE ENLPPIRNGN
FRKKKKGKAK ETSKKTKDEN TKNRIKSYDY EAWAKLDVDS ILDELDKEES THDSVSQESE
SEEDGIHVDS QKALALKEKG NKYFKQGKYD EAIECYTKGM DADPYNPVLP TNRASAYFRM
KKFAVAESDC NLAIALNRSY TKAYARRGAA RFALQKLEDA KKDYEKVLEL EPNNFEATNE
LRKINQALTS KENSCPKEAD IMIKSTEGER KTEEQRNKLQ AISEKDRGNG FFKEGKYERA
IECYTRGIAA DGANALLPAN RAMAYLKIQK YEEAEKDCTQ AIFLDGSYSK AFARRGTART
FLGKLNEAKQ DFETVLLLEP GNKQAATELA KIKKELIDKG HWDDVFLDST QRQNVIKPID
NPPHLGSTKP LKKVTIEETG NLIETVEVPE SSTVAAALES DPTNLAGVIA TTGAAAKNSS
QDDLLPTSDF PKAKVLKIEE ISDASGPQPQ INLKQDVCQS FSEKISIEVD KTPAQFTTTV
LPQVPANSFQ LESDFRQLKN SPEMLYQYLK QIEPSLYPTL FQKNLDPDVF NQIIKILHDF
YIEKEKPSLI FEILQRLSEL KRFDMAVMFM SEPERKSPEF SSTTWPKPMK QKPGTLLSQS
LQQFTALHED GCYLRRLRIS VCSLPTGTWL PLLLGLLRKS RKRLGHAQRE DHVKTRGRDG
YLQAKERLLQ KEQALLTP
//
