ID F7DRB9_HORSE Unreviewed; 1095 AA.
AC F7DRB9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 4.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Contactin-5 {ECO:0000256|ARBA:ARBA00044127};
GN Name=CNTN5 {ECO:0000313|Ensembl:ENSECAP00000000883.4,
GN ECO:0000313|VGNC:VGNC:59382};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000000883.4, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000000883.4, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000000883.4,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000000883.4}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000000883.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. Contactin
CC family. {ECO:0000256|ARBA:ARBA00009812}.
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DR AlphaFoldDB; F7DRB9; -.
DR Ensembl; ENSECAT00000001108.4; ENSECAP00000000883.4; ENSECAG00000000340.4.
DR VGNC; VGNC:59382; CNTN5.
DR GeneTree; ENSGT00940000158183; -.
DR HOGENOM; CLU_005756_0_0_1; -.
DR TreeFam; TF351103; -.
DR Proteomes; UP000002281; Chromosome 7.
DR Bgee; ENSECAG00000000340; Expressed in brainstem and 5 other cell types or tissues.
DR GO; GO:0098982; C:GABA-ergic synapse; IEA:Ensembl.
DR GO; GO:0042734; C:presynaptic membrane; IEA:Ensembl.
DR GO; GO:0099054; P:presynapse assembly; IEA:Ensembl.
DR GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR CDD; cd00063; FN3; 4.
DR CDD; cd04969; Ig5_Contactin; 1.
DR CDD; cd05848; IgI_1_Contactin-5; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR44170:SF17; CONTACTIN-5; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 4.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 6.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor {ECO:0000256|ARBA:ARBA00022622};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00022622};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1095
FT /note="Contactin-5"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040430461"
FT DOMAIN 94..185
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 202..277
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 295..380
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 385..469
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 475..562
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 566..655
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 668..766
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 771..868
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 873..967
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 972..1062
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 954..978
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 956..978
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1095 AA; 120099 MW; E27AA3410E8D354B CRC64;
MASSWTLILF LSVSGCLSEY SGALPGLPTS YAALLRIKKS SSSSLFGSKT RPRYSSPLLG
TPSWRGAAQH YYSPNNLYHS SDAFKQDESV DYGPVFVQEP DDIIFPADSD EKKVALNCEV
RGNPAPNYRW LRNGTEIDLE SDYRYSLIDG TFIISNPSEA KDSGHYQCLA VNTFGSILSR
EAILQFAYLG NFSGRTRSAV SVREGQGVVL MCSPPPHSPE IIYSWVFNEF PSFVAEDSRR
FISQETGNLY ISKVQTSDVG SYICLVKNTV TNARVLSPPT PLTLRNDGVM GEYEPKIEVH
FPFMVTAAKG TTVKMECFAL GNPVPTITWM KVNGYVPSKA RLRKSQAVLE IPNVQLDDAG
IYECRAENSR GKNSFRGQLQ VYTYPHWVEK LNDTQLDSGS PLRWECKATG KPRPTYRWLK
NGVPLLPQSR VEMVNGVLMI HNVNQSDAGM YQCLAENKYG AIYASAELKI LASAPTFALN
HLKKTIIVTK GQEVTMECKP QGSPKPTISW KKGDKAVREN KRIAILPDGT LRILNASKSD
EGKYICQGEN VFGSAEIIAS LSVKEPTRIE LTPKRTELTV GESIVLNCKA IHDASLDVTF
YWTLKGQPID FEKEGGHFES IRAQASSADL MIRNILLMHA GRYGCRVQTT ADSVSDEAEL
LVRGPPGPPG IVIIEEITES TATLSWSPAA DNHSPISSYN LQARSPFSLG WQTVKTVPEI
ITGDMESAMA VDLNPWVEYE FRVVATNPIG TGDPSTPSRM IRTNEAVPKT APTNVSGRSG
RRHELVIAWE PVSEEFQNGE GFGYIVAFRP NGTRGWKEKM VTSSEASKFI YRDESVPPLT
PFEVKVGVYN NKGDGPFSQI VVICSAEGEP SAAPTDVKAT SVSVSEILVA WKHIKESLGR
PQGFEVGYRK DMEQEDAAET VKTRGNESSV ILTGLEGNTL YHFTVRAYNG AGYGPPSSEV
SATTKKSPPS QAPSNLRWEQ QGSELSLGWE PVRPLANESE VLGYKVFYRQ EGHSNSQVIE
TQKPQAVVPL PDAGVYIIEV RAYSEGGDGT ASSQIRVPSY SGGKITSAQS TLHTLSTSSS
SVTLLLALML PSTSW
//
