ID F7DS46_ORNAN Unreviewed; 940 AA.
AC F7DS46;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Espin like {ECO:0000313|Ensembl:ENSOANP00000024554.2};
GN Name=ESPNL {ECO:0000313|Ensembl:ENSOANP00000024554.2};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000024554.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000024554.2, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000024554.2,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000024554.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000024554.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, stereocilium
CC {ECO:0000256|ARBA:ARBA00004645}.
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DR AlphaFoldDB; F7DS46; -.
DR Ensembl; ENSOANT00000024558.2; ENSOANP00000024554.2; ENSOANG00000015589.3.
DR GeneTree; ENSGT00940000156970; -.
DR HOGENOM; CLU_017253_0_0_1; -.
DR InParanoid; F7DS46; -.
DR OMA; MPNTDLI; -.
DR Proteomes; UP000002279; Chromosome 7.
DR Bgee; ENSOANG00000015589; Expressed in testis and 2 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0032420; C:stereocilium; IEA:UniProtKB-SubCell.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0051017; P:actin filament bundle assembly; IBA:GO_Central.
DR GO; GO:0007605; P:sensory perception of sound; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR24153; ESPIN; 1.
DR PANTHER; PTHR24153:SF0; ESPIN-LIKE PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF13637; Ank_4; 2.
DR SMART; SM00248; ANK; 9.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 5.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hearing {ECO:0000256|ARBA:ARBA00022740};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 103..135
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 136..157
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 171..193
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 239..271
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 271..303
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 548..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 585..670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 699..729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 871..915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 461..488
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 626..644
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 940 AA; 102699 MW; A5EA2BF2D24B709C CRC64;
MGDQRAILAA RDGDLTTLER LFEDGLLKQG VTDAQGAGPV HHASRGGHLE CLKFLVQRAE
LPGNQRAKNG ATPAHDAAAT GHLAELQWLM RDGGCGVQVQ DVSGVSPLHL AARFGHPMVV
EWLVREGYDP AAETLEGASP VHYAAAKGDL TCLKLLVAAD PRNCVDKQTR SGASPLYLAC
QEGHLHVAQF LVKDCGANVH LRAHDGMTIL HAAACSGHYS LVVWLVTFTD VGLAAQDDEG
ATALHFAARG GHTPIVDRLL LMGAEITKDH WGGTPLHDAA ENGQLECCRT LIVHHVDPTL
LDGDGYTARD LAEYNGHRDC TLFLQQVETL AQVKSPTPSL PPSPTIQAVW PPDAGKIPVQ
GEKMEAFEDL GKSLISLRLK ELNQSDADAL VPTHDERGYP IPEWKRQVMV RKLQARLLSE
ETLSQKEGGG SMEVSDWRYS QAHNAILGSY GELLTEDDLM YLEKQIENLQ LKKKCRDYER
ELGRLAEELQ ALLPPPIVNV SVHGRPRRDP GAEGEGQALP MWCSRVSGAA KSMSLPLRNM
NGLVSREEKS AGGLPARAVP DPPGGSVERE ILGCGVSVRS LRDSFEKQAC SEPQKPAQPQ
EAKMGPGGPL RGAHPLGGTG PHKIQAGDKS QKRQLREERA SGDPKVATDA GIGCEEASSG
TNGSPVAESA SLRKERIVTL FLSHWKKSAY TPALKTAARR SLESRRARRK GREVAPIGPG
AEQSDGKPPL REIGKLAHLL QQRNAIKNLL GDWKDIISHV PSRQIRRLNR QPVTYSPEQF
LPYVNGAPVP HDSLTLDLFM LGYFHILDLD LPAEERKTRH LLCFEVFDHL GSHSWETVRA
FHRAVIGEIE AGRRGWTDGF EDIKERFFGP DKGPAREIEA GQRKPSPGAA APSRCLEPRG
RLSGTFSGSR GFSSDDICGY IDRSFAFWKE KEAEMFDFRE
//
