ID F7DW96_XENTR Unreviewed; 1046 AA.
AC F7DW96;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Nuclear export mediator factor {ECO:0000313|Ensembl:ENSXETP00000020018};
GN Name=nemf {ECO:0000313|Ensembl:ENSXETP00000020018};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000020018};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000020018}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000020018};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000020018}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NEMF family.
CC {ECO:0000256|ARBA:ARBA00008318}.
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DR AlphaFoldDB; F7DW96; -.
DR STRING; 8364.ENSXETP00000020018; -.
DR DNASU; 780151; -.
DR Ensembl; ENSXETT00000020018; ENSXETP00000020018; ENSXETG00000027739.
DR AGR; Xenbase:XB-GENE-5772016; -.
DR AGR; Xenbase:XB-GENE-972101; -.
DR Xenbase; XB-GENE-5772016; nemf.
DR eggNOG; KOG2030; Eukaryota.
DR HOGENOM; CLU_003612_1_0_1; -.
DR InParanoid; F7DW96; -.
DR OrthoDB; 5474929at2759; -.
DR TreeFam; TF300515; -.
DR Bgee; ENSXETG00000027739; Expressed in testis and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProt.
DR Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR InterPro; IPR021846; NFACT-C.
DR InterPro; IPR008532; NFACT_RNA-bd.
DR PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR PANTHER; PTHR15239:SF6; RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF; 1.
DR Pfam; PF11923; NFACT-C; 1.
DR Pfam; PF05670; NFACT-R_1; 1.
DR Pfam; PF05833; NFACT_N; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}.
FT DOMAIN 511..621
FT /note="NFACT RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF05670"
FT DOMAIN 945..1036
FT /note="NFACT protein C-terminal"
FT /evidence="ECO:0000259|Pfam:PF11923"
FT REGION 404..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 658..947
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1019..1046
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 291..328
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 466..493
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 678..695
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 733..750
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 797..824
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..840
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 848..864
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 874..896
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 903..929
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 930..944
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1046 AA; 118940 MW; 9DE34339A68F7710 CRC64;
MTFFLCYSLL GLRVHNVYDV DNKTYLIRLQ KPDSKAVLLV ESGIRIHTTE FEWPKNMMPS
GFAMKCRKHL KSRRLVSIKQ LGVDRIVDFQ FGSDEAAYHL IVELYDRGNI VLTDHEYLIL
NILRFRTDEA DDVKFAVREH YPIDHAKAPE PLLSVEKLKE ILEKAQKGDQ LKRVLNPHLP
YGATLIEHCL LDTGLSSNVK VDQISGPEDL EKVHTALRKA EEYMDVTQHF KGKGFIIQKR
EKKPSLEPDK PSEDIFTNEE FHPFLFAQHC NNTYIELDSF NKAVDEFFSK MEGQRIDLKA
LQQEKQALKK LENVRKDHEE RLESLQHAQD ADKAKGELIE MNLDIVDRAI QVVRSALANQ
IDWKEIGLIV KEAQIQGDSV ALAIKELKLQ TNHITMLLKN PYTLSEEGSE DEEEEKEEEP
KGKKKKSKNK QPKKVQKNKP VLVDVDLSLS AYANAKKYYD HKRHAAKKSQ KTIEAAEKAF
KSAEKKTKQT LKEVQTVSTI QKARKVYWFE KFLWFISSEN YLVIAGRDQQ QNELIVKRYL
NPGDVYVHAD LHGATSCVIK NPTGEPVPPR TLTEAGTMAV CYSAAWDARV ITSAWWVHHN
QVSKTAPTGE YLTTGSFMIR GKKNFLPPSY LMMGFGFLFK VDEPCVWRHK GERRVKQLDE
DMESVTSSNT ELAAEENIPL DAAEEDSNSS EEDEKLDTQE EQRGPCTDSM GLEQKEYMVP
ADQNSDQESS NSEENSTIKE EAEKELSYPD TAIDLSHLQT KRTLSKAAPA ELVDTPLENE
KSSGRKHMSA KEKRELKKKK KPNDKDEFQP SEQKETDDKK DVADSQSAPQ ASTGNQPMKR
GQKSKLKKIK EKYKDQDEED RDLIMQLLGS AGSNKEDKGK KGKKGKMKEE PVKKPPQKAK
GGGPRPVKRE GPADVFLTED LHEMTLEEQQ EDKEEADQDP QGTEEAENLL DSLTGQPHGE
DVLLFSVPVC APYTSMTNYK YKVKLTPGTH KKGKAAKTAL NSFMHSKDST VREKDLLRSV
KDTDLSRNMP GKVKVSAPNL LNTKKK
//
