ID F7E0E7_HORSE Unreviewed; 1076 AA.
AC F7E0E7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=NLR family pyrin domain containing 2 {ECO:0000313|Ensembl:ENSECAP00000017692.2};
GN Name=NLRP2 {ECO:0000313|Ensembl:ENSECAP00000017692.2,
GN ECO:0000313|VGNC:VGNC:112238};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000017692.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000017692.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017692.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000017692.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017692.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR AlphaFoldDB; F7E0E7; -.
DR STRING; 9796.ENSECAP00000017692; -.
DR PaxDb; 9796-ENSECAP00000017692; -.
DR Ensembl; ENSECAT00000021481.3; ENSECAP00000017692.2; ENSECAG00000020087.3.
DR VGNC; VGNC:112238; NLRP2.
DR GeneTree; ENSGT00940000161714; -.
DR HOGENOM; CLU_002274_2_1_1; -.
DR InParanoid; F7E0E7; -.
DR OMA; KMLTGPF; -.
DR Proteomes; UP000002281; Chromosome 10.
DR Bgee; ENSECAG00000020087; Expressed in blood and 1 other cell type or tissue.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0050727; P:regulation of inflammatory response; IBA:GO_Central.
DR CDD; cd08320; Pyrin_NALPs; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF14; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 2; 1.
DR Pfam; PF13516; LRR_6; 3.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00368; LRR_RI; 8.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 1..98
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 214..412
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REGION 129..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1056..1076
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1076 AA; 121562 MW; AFC01BFBDEAA3FA8 CRC64;
MVPSGQLDFN LQPLLERLDQ DELSQFKSLL RTLSLQDELQ HIPQTEVEEA SGKQLAEILT
NRCPRNWVEM VTIQVFDKMN RTDLSERAKD ELKEAALKSL QENKPPSLGI TWTQESKREN
LEEIQQHLKE EEEPELTPVQ KEDITNSGEA KEGLAGENPG KQDKYRSIMK KKFCQIWEKN
FWPGASENVH IVTQRYETLI PFCNPKMLTG PFPHTVVLHG PAGIGKTTLA KKLMLDWTQD
NLAETFNAAF YLSCKELNHK GACTFAELIS KNWPDLQDAI PEIFAQAQKV LFIIDGFDEL
RVPSGALIHD MCCDWQKQKP VPVLLGSLLK RKILPKATLL ITTRPGTLRE LRLLVEQPLF
IEIEGFLELD RKAYFLKHFE EEVQALRAFD LMKSNAALFH LGSAPAVCWI VCTCMKLQME
KGEDPAPTCQ TITSLFLHFL CSQFTSPPGS CPGPFLQVPV TALCLLAAGG IWTQTSMFDG
EDLERLGVKE SDFHPFLDKN ILQKGKDCEG CYSFIHLSVQ QFLAALFYVL EREEEEDGDS
CRWDIGGVQK LLSKEERLKN PSLTHVGYFL FGLLNEKRAR ELETTFGCQV SLKIKQELLE
CRVKSTENKP LSVTEMQEVL YCLYESQEER LVKDAMAHIK ETSLHLKNKM DIIHASFCLQ
HCRNLQKISL QVEKGVFLEN DTASESDTQV ERFQNDEHVL PFWMGLCSIF GSNKNLIFLD
ISQSFLSTSS VKILCEKIAS ATCNLQKVVL KNISPADAYQ NFCITFGGHK TLTHLTLQGN
DQDDMFPSLC SVLRHPKCHL QYLSLVSCSA TTHQWADLSS SLEINQSLTC LNLTANELLD
EDAKLLYMTL RHPKCFLQRL SLENCHLTEA SCKELSSALI VNQRLTHLCL AKNALGDGGV
KLLCEGLSYP ECQLQTLVLW YCNITSDGCN HLSTLLQQNS SLMHLDLGLN HIGIIGLKFL
CEALKKPLCN LRCLWLWGCA ITPFSCEDLS SALSSNQNLT TLDLGQNSLG YSGVKVLCDA
LKLQSCPLQT LRLKIDESDA RIHKLLKEIK DSNPQLTIES DQDPENNRPS SRDFIF
//
