ID F7E182_XENTR Unreviewed; 1907 AA.
AC F7E182;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Bromodomain and WD repeat domain-containing 1 {ECO:0000313|Ensembl:ENSXETP00000051195};
GN Name=brwd1 {ECO:0000313|Ensembl:ENSXETP00000051195};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000051195};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000051195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000051195};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000051195}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
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DR Ensembl; ENSXETT00000051195; ENSXETP00000051195; ENSXETG00000023728.
DR AGR; Xenbase:XB-GENE-992020; -.
DR Xenbase; XB-GENE-992020; brwd1.
DR eggNOG; KOG0644; Eukaryota.
DR HOGENOM; CLU_001108_0_0_1; -.
DR TreeFam; TF324197; -.
DR Bgee; ENSXETG00000023728; Expressed in 4-cell stage embryo and 12 other cell types or tissues.
DR CDD; cd05529; Bromo_WDR9_I_like; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR006594; LisH.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR16266:SF26; BROMODOMAIN AND WD REPEAT-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR16266; WD REPEAT DOMAIN 9; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50896; LISH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 181..222
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 223..264
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 265..301
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 363..394
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 461..503
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1133..1203
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 641..700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 746..903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1232..1254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1341..1510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1523..1845
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1873..1895
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..700
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 785..799
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 807..824
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 849..880
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1348..1383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1396..1427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1435..1449
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1460..1482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1483..1505
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1534..1579
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1580..1619
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1635..1664
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1665..1685
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1696..1740
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1757..1776
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1779..1808
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1809..1845
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1873..1888
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1907 AA; 214303 MW; CCA2C08F279E275D CRC64;
MAEPPGPSRS PQQLETELHF LIARFLSNGP YHKTAEVLIR QMNESKAFPK RLDWLGNEHG
RSFEEMVSAN NHVSSDHLLK ICQHLGSLLD NITPCNVQTG SLLGAGKQSL LRTEKGCKNV
QWNRQMLAAL HRGRPPEMPI NIRFPPNAAV VHYGKRLTGT LSITSGFPVQ LYQHMKMHRR
ILGHRSSVYC VAFDRTGHRI FTGADDGLVK IWSTHDGRLI ATLRGHSAEV SELTVNYENT
LIAAASCEKI IRVWSLRTCA PVAVLQGHSI SVTSLLFSPL VDGSMRYLIS TGGDATVCCW
EWDVDTLQFK DQPIKFTEKS GPGAQMLCCS CSAGGMYLAT GGSDRAIRIY FFGCETPKKL
IQLEGHNDII DSVQFANSGE RFVSGSNDGT ARIWYLHEQN WKSIRLDMRE GDKDSEEEEQ
LTRPKVLMIT WDLTDATVVT ASNLRSLKVW ESRTGKLLRV LSGHQNDIYV LEPHPFDSRV
MISAGYDGKI IIWDVNKGDQ IKCYCNTIEH EGHGAILDCK LSVDGQHIAS TDSHGHLLIF
GFGCSKPYEK IPDEMFFHTD YRPLCIDGNH YVLDEQTQLA PHLMPPAFLV DSDGNPHEPK
FQRLVPGREN FEDEHLIPQL GYMETSDGEI VEQVIGQQAS DDLQNAEPSS QEGMRPPQIA
DGQRRDASSS PSTGSSRNGQ AQGVRQSQSS SPQSQTSADR DYLAWRRRVV VPELERNVYR
QQEASRLERG REEKAYFAKQ ILQPSVQETH LPTERQNARS IKRPKCRSPS PRPDVEQFLD
LSCEEGEETE SRGSEEEIST VDDTSSTAST DKEEEWRSEE SSEYSDWTVD AGINLQPPSR
ISTRRRVKTI MTSSEEESSA EERLSTPKKR RPKQRHSDSE MQSPGRPLSD RENPTDFHPP
LWITDTLPRR SPFVPQMGDD VIYFRQGHEA YINVVRRNNL SILKKLKEPW KHVILRDQEL
VKIVGIRYEV GPPSLCCLKL ALIDHVTGKF IDQSFSLKYH DMPDVIDFLV LKQFYDQSCQ
TNWHPGDRFR SIIDDAWWFG TVMDQEPYQS DYPDSLFQCY TVKWDNTEVE RLSPWDMEII
PAYVSPPSEL GTSISLNSDE LEELLYVPQK GEWGNGDRDS ECERVICGID QILQMEFASQ
FAAPVDLTTY PIYSSVVSYP TDLSTIRMRL VNRFYRRLSA LIWEVRYIEL NARAFNEPDS
SIAKSAKIIT DLLLRFIMDS RCTNISDLCN AAEGDEEEEE SADEQKQKRK DKMAKSKEDA
WRMQCMELAN SVLENEDSEP FREPVDLYEY PIHSMVLRLS EFVESRMDAI ISEYKAAYSC
KQAENDLNYL KSTSRNVKQR RLISESENES GQEPCSSRST SSEVFSNNSR DSIASTSGAS
SYRDVLGKPT ASAAKSAPVI ATSSSSSSSA SSGSETDSSS STSDSEHSSG SEKAESNKKS
VSNSHAGKVS VFVKSVDPAK RNGRTTTTKQ ESQGNRQQNM TSSKRRHNSD SEESVPKDKA
YSTSRTQKKM LRKCAALAAN KIKCMSDTEG SMPSSDSDCR EGKGSRTLPR RAAATEAKKH
LMDGSGEENT LKSDNDRQPR MEQSASNVSA LCASKAVSRR SDSSGSESRS KSPSSGESSI
SDEIEDDHPV NGENSDQEMS EPSIADTPYK HSATSWLVSE SDSEISSTED TRQVTKQKHY
VPKTKIAAER NSSSKNTNKE TTKKDLTNCR KNRKKYTDKA NEWVSDSTDS DSEAGVIKRK
VRKKVVFSLT SPARKTKVTS DSEDTLDSED YGKFSGSDEE IPQSKSIKST ESSSESSSSS
SDSGSSLSDA SSHHERKVNG KTVALKPREP EGKRKRTKSS CDDDWEELNY RQRKKLTRRA
KIPTRNRGKR TVRYDDVDSE ETVSRTKSTN RRLRKISARA SARQFFL
//
