ID F7E2V1_XENTR Unreviewed; 1398 AA.
AC F7E2V1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 24-JAN-2024, entry version 73.
DE SubName: Full=Pleckstrin homology and RhoGEF domain containing G3 {ECO:0000313|Ensembl:ENSXETP00000001741};
GN Name=plekhg3 {ECO:0000313|Ensembl:ENSXETP00000001741};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000001741};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000001741}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000001741};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000001741}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
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DR STRING; 8364.ENSXETP00000001741; -.
DR Ensembl; ENSXETT00000001741; ENSXETP00000001741; ENSXETG00000036106.
DR HOGENOM; CLU_008658_3_0_1; -.
DR OrthoDB; 5324584at2759; -.
DR TreeFam; TF300693; -.
DR Bgee; ENSXETG00000036106; Expressed in mesonephros and 13 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13243; PH_PLEKHG1_G2_G3; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR043324; PH_PLEKHG1_G2_G3.
DR PANTHER; PTHR45924; FI17866P1; 1.
DR PANTHER; PTHR45924:SF4; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 188..369
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 393..491
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 149..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 519..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 635..689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 854..894
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1107..1151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1172..1208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1224..1255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1332..1372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..55
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..77
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 538..574
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..610
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..666
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 854..881
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1107..1136
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1224..1241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1332..1363
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1398 AA; 157653 MW; 6B68995FB5ABE49E CRC64;
MSTAPGLQTL WLSKVGSEGE EPQTLHSKET STDGDLLTSE SLRRHSKDDR QLLFLEETSH
QGNDESPRLS AASSSSNEKL SISASICSDS DRPLSLFSTE STGSLREGCD SYEDNSDVPL
GNGTVVHNME LVATAAESLQ ATYREMQNGL RNNHTPNNNS ANRRSHQASR SLSPFGNKVN
AITHKLSYVE RVVLEINDTE RMYVQDLRSI VEDYLGAIID RQEELPITPE QVCALFGNIE
DIYELNSELL QDLDNCRNDP VAVASCFVEK SQDFDIYTQY CTNYPNSVAT LTECMRNKTL
AKFFREKQEM LNQSLPLGSY LLKPVQRILK YHLLLQEIAK HLDVKVEGYE VLEEAIETMT
GVAWYINDMK RKHEHAVRQQ EIQSLLLNWK GIDLTAYGEL VLEGTFRLQR ARSERTFFLF
DKALFITKRR GDHYVYKTHI PCSSLMLIES ARDSLCFSVT HYKNSKQQHN VQAKTVEEKH
VWTHHIKKLI LENHHAIIPQ KAKEAILEMD NMYKGRYKYS PERQKKTMSA IEPSMTHRSG
RRQSEPSKDI LKQLNDKAGL KTKDPVEEEA PKGCKRQNSQ SSGNAEKRRS VEVTSGHQES
VYKMDKENSE PEEIYKAVVV SSSEDEQAVL LEITDDTEPA KDDSAAHPEV LEPVENEEAE
STEDSKTFSS EEEEEETPTH ESTSILPPSV LDQASVIAER FISSMSRRSS MALDDGKVIG
YITPRLTSRC SSLINLESTD TIIYQNGSSD FQDFSEVCGD TGVDILDTTF SKVNSASMEN
VFEERERPTC KRRDSILSMQ DRQLIDKIRT YYDDAENRDA SFSIKRRESL NYIPTGLVRN
SVFKINSLPR FDTTQSSLSR QRMSSSSSNT SGVNSRHASL TDTRSNARES EQLETQTELL
LETATNGTSD HSAPITDEEF RTPDEMIKVW DEFEKVNAWK EASDILEAKK DVKPDSVGES
TAHCALENGL ESHEPLLILE DSDLSTITEE SPLPTPESTS PKQFGCVPNN TSFSEYKTPV
KLHSKIMQMA SCMDEDMSEK MKNKVYQLAR QYSQRIKCNK PVSQRQLKEI EEDFRRNSLP
AVQEEKLDKK EKRKPILSLP TYDSVILQEH GPTTPTSALS RDTAPKHLSF SPSCDSPRAL
SPERADCRSP LSPVKAERFH WPDVRELRSR YTSAASSSKA PPVNRSQSVP ERITVPNLRG
HSDTQSKGCL IHSHSMNVKH TENVNGSAED SAQNNKAQVE TEPPLPVSPS LKGKTDSLLG
SAKPGYYISA EAPLENNKKV IVMEKIPAAT DSNGSHDVES DDTYVQIRSP TSREKISLKA
VIERCKAYQE SEEYRSREVA SKDGETTECT ESVPHEEPNL ERHVAPSCDV NQQNRVKNLR
EKFQTKHNSS SLKQSEVH
//