ID F7E412_XENTR Unreviewed; 430 AA.
AC F7E412;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Neuropeptide FF receptor 1 {ECO:0000313|Ensembl:ENSXETP00000013519, ECO:0000313|RefSeq:XP_004915843.2};
GN Name=npffr1.1 {ECO:0000313|Ensembl:ENSXETP00000013519,
GN ECO:0000313|RefSeq:XP_004915843.2,
GN ECO:0000313|Xenbase:XB-GENE-987767};
GN Synonyms=npffr1 {ECO:0000313|Xenbase:XB-GENE-987767};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000013519};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000013519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000013519};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000013519}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_004915843.2}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_004915843.2};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_004915843.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide)
CC neuropeptides, also known as morphine-modulating peptides. Can also be
CC activated by a variety of naturally occurring or synthetic FMRF-amide
CC like ligands. This receptor mediates its action by association with G
CC proteins that activate a phosphatidylinositol-calcium second messenger
CC system. {ECO:0000256|ARBA:ARBA00025478}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR RefSeq; XP_004915843.2; XM_004915786.4.
DR Ensembl; ENSXETT00000013519; ENSXETP00000013519; ENSXETG00000006144.
DR KEGG; xtr:101733377; -.
DR AGR; Xenbase:XB-GENE-922463; -.
DR AGR; Xenbase:XB-GENE-987767; -.
DR Xenbase; XB-GENE-987767; npffr1.1.
DR eggNOG; KOG3656; Eukaryota.
DR HOGENOM; CLU_009579_6_1_1; -.
DR OMA; WGSHREA; -.
DR OrthoDB; 5397809at2759; -.
DR TreeFam; TF315303; -.
DR Proteomes; UP000008143; Chromosome 7.
DR Bgee; ENSXETG00000006144; Expressed in brain.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008188; F:neuropeptide receptor activity; IEA:InterPro.
DR CDD; cd15981; 7tmA_NPFFR1; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR005395; NPFF_rcpt.
DR InterPro; IPR005396; NPFF_rcpt_1.
DR PANTHER; PTHR24241:SF4; NEUROPEPTIDE FF RECEPTOR 1; 1.
DR PANTHER; PTHR24241; NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01570; NPFFRECEPTOR.
DR PRINTS; PR01571; NPFFRECEPTR1.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688,
KW ECO:0000313|RefSeq:XP_004915843.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 37..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 116..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 154..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 55..326
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 430 AA; 49229 MW; 089BFFE9DFF3C719 CRC64;
MEGPLPFNIS SPGHGNTTQA SRDNFTFSLY YQHSTSIAAM FILAYTFIFL MCMIGNMLVC
FIVLKNRQMR TVTNMFILNL AISDLLVGIF CMPTTLVDNL ITGWPFDNIM CKMSGLVQGM
SVSASVFTLV AIAVERFRCI VYPFRQKLTL RKAIITIIII WVLALIIMCP SAVTLTVTKD
DFHFMVDDYN NYYPLYSCWE EWPDTEMRKI YTTVLFSHIY LAPLTLIVIM YARIAFKLFK
SSAPIRGSVS EENEGRRVSK RKVRVIYMLI IVALFFSLSW LPLWTLMLLT DYGHLSDYQL
NLIAVYVFPF AHWLAFFNSS VNPIIYGYFN ENFRRGFQEA FKVQVCSMKR EHRETYSERK
NSGFLFGVRN RIFVEVQPSD SGQGSDSCNS TAKGGMFSLR SGRIAHHGLV VEDVDNKSSN
NTVSVPAWEI
//
