ID F7ESB4_XENTR Unreviewed; 738 AA.
AC F7ESB4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Heterogeneous nuclear ribonucleoprotein U-like 2 {ECO:0000313|Ensembl:ENSXETP00000013246};
GN Name=hnrnpul2 {ECO:0000313|Ensembl:ENSXETP00000013246};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000013246};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000013246}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000013246};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000013246}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; F7ESB4; -.
DR STRING; 8364.ENSXETP00000013246; -.
DR DNASU; 493266; -.
DR Ensembl; ENSXETT00000013246; ENSXETP00000013246; ENSXETG00000006015.
DR AGR; Xenbase:XB-GENE-492973; -.
DR AGR; Xenbase:XB-GENE-958837; -.
DR Xenbase; XB-GENE-492973; hnrnpul2.
DR eggNOG; KOG2242; Eukaryota.
DR OrthoDB; 3106766at2759; -.
DR TreeFam; TF317301; -.
DR Bgee; ENSXETG00000006015; Expressed in gastrula and 13 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd12884; SPRY_hnRNP; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.720.30; SAP domain; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003034; SAP_dom.
DR InterPro; IPR036361; SAP_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR035778; SPRY_hnRNP_U.
DR PANTHER; PTHR12381; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U FAMILY MEMBER; 1.
DR PANTHER; PTHR12381:SF66; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U-LIKE PROTEIN 2; 1.
DR Pfam; PF13671; AAA_33; 1.
DR Pfam; PF02037; SAP; 1.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00513; SAP; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF68906; SAP domain; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50800; SAP; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 698..718
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 6..40
FT /note="SAP"
FT /evidence="ECO:0000259|PROSITE:PS50800"
FT DOMAIN 212..404
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 69..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 619..645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..93
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..129
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..221
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 738 AA; 83792 MW; 47002B4888CE1F5E CRC64;
MSGLDPRRMK VTELRAELQR RGLESRGLKA ELCERLQEAL DSELLGGDEE KGAFIQEMAG
GDEELALELG DEEDEEEMLH EGQEDEEEDF NPNEVEAVAA QENDAVPVKK QLEEETDSQA
EKIEPPPVVE EEESDMGVES LNGAASKTDP GDSVAEECGD EEKSETAESS QNKVELADSR
SSEPKRYGVK RIREDEQNGR TYHEFKEEAY YSRSKSPVPP EEEDSEVDEN IVCLDKLTCD
LQLKLDKDQF GGRPLFYEKF PSLWSGSRAT HGVTKGKVYF EIKVTENLPQ KEGCTETPLL
RVGWSVAQSS SQLGEDDLSY AYDSRGLKVT SSHFDPYGDT FGENDVIGCF ADLEGDSVDL
FFSKNGENLG EAFHLEKEVA DQPLFPHVLC KGCVFQVNFG QKDEAWHPPP DGFIFLKDAQ
PEDLARSLES PETEEYEVLL MIGLPGSGKT TWALNHSQEN SEKKYLLLST DILLPQLKTA
GPDPQQEDSK AKDSLTQLAT QCLIRLIPLA ARRKRNYIID QCTVYNSAQR RKMNCFKGFQ
RKAVVVVPSE EEWKKRVEQR KEKEGEIIPE TVLLEMKANF NIPKKTDYLH EILYPELDCD
EAEALIIAAK KEARQLLPAP EKRGNRMHKR NRSDRGRGGY HGTGNYQQRD YGNRMFMNHP
RQQMYHQQQQ RSYWSPPLWG TNCLACTVWG LLLYVRLSIL NLCSALMYCL WLSVLLYLRL
LSCSTVMPCR AFRVQNLV
//
