ID F7ET68_ORNAN Unreviewed; 1525 AA.
AC F7ET68;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 2.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=Zinc finger FYVE domain-containing protein {ECO:0000256|PIRNR:PIRNR037289};
GN Name=ZFYVE16 {ECO:0000313|Ensembl:ENSOANP00000002577.2};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000002577.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000002577.2, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000002577.2,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000002577.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000002577.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR037289}. Early
CC endosome membrane {ECO:0000256|PIRNR:PIRNR037289}.
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DR RefSeq; XP_001510291.1; XM_001510241.3.
DR STRING; 9258.ENSOANP00000002577; -.
DR Ensembl; ENSOANT00000002578.3; ENSOANP00000002577.2; ENSOANG00000001613.3.
DR eggNOG; KOG1841; Eukaryota.
DR GeneTree; ENSGT00940000154290; -.
DR HOGENOM; CLU_004326_0_0_1; -.
DR InParanoid; F7ET68; -.
DR OMA; GIDKYVC; -.
DR OrthoDB; 3061552at2759; -.
DR TreeFam; TF324904; -.
DR Proteomes; UP000002279; Chromosome 1.
DR Bgee; ENSOANG00000001613; Expressed in ovary and 8 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-UniRule.
DR GO; GO:0031901; C:early endosome membrane; IBA:GO_Central.
DR GO; GO:0005545; F:1-phosphatidylinositol binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR GO; GO:0006622; P:protein targeting to lysosome; IBA:GO_Central.
DR CDD; cd15729; FYVE_endofin; 1.
DR Gene3D; 3.30.500.40; -; 1.
DR Gene3D; 3.30.1360.220; Domain of unknown function (DUF3480), N-terminal subdomain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR022557; SARA-like_C.
DR InterPro; IPR035438; SARA/endofin.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46319; ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46319:SF1; ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 16; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF11979; SARA_C; 1.
DR PIRSF; PIRSF037289; SARA/endofin; 1.
DR SMART; SM01421; DUF3480; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR037289};
KW Endosome {ECO:0000256|PIRNR:PIRNR037289};
KW Membrane {ECO:0000256|PIRNR:PIRNR037289};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRNR:PIRNR037289};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 725..783
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 29..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 616..654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 792..831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 866..892
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..643
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1525 AA; 166180 MW; 5323E095E6B8DD05 CRC64;
MDSYFKAAVC DLDKVLDDFE KNTGEHEHYQ KEASCSDSSE LPPSQPASLA PKIQQHLSNC
LSSQAIFITN QTAANGKNLE GVSSSVQNEK NVTGLDLLSA VDGGSSVEIQ PSSQGRCSIP
VCDLVSDTGN LVLAKSSHED SQALRPDDFQ SGKDSLIGLD LSSLPSTICT SLEDDGCNAA
IEKQNGDHSP LQNIEHLAAR KLDFKSCNHL DTAFLDSSDH KIAGNLRENK IHNLEQIAGL
NSALTQQNSK TLNSKDDTIP KKLPCELLKD NGCLRQEVHT GKTDTTDLKE SVVSGVPCDL
PKSKELYPPD RNIRLPDCFL SPLKEESTEE NSRTLVLTNN NNMLQNGACG DVQSSLSCLP
ISMSLCGSLI ETKAQGDCVS QIGQEDGIVE DETVHKDIPK SGGLHGDLFT VTEPSELKEC
ANRAEEKVEK VIDRVADHDQ LVSTTEFSPC HTNLPVAADS LEPSGCVSPL FNDHHENDTL
SSKDIISQVL EDFNIDDAIK DQALISDAEL DAFLTEQNLQ TPTRKSLEDV GDLESQMNEI
NIKEPSVEET ANASLRSEDE ETCDITRSGE TIDAQGESES EGLFSGEQST ILIQKDASDN
IAEVANELSA SSINGQTIHA GGARPKQLSN LPSITITPKE SNKLKAQNRT EADDQLVNST
APTVRPGEAR IDPNMSCTSI PADLENNLGN GENSFSTSTE SVSLAERTCK EGMVLGHKQP
SWVPDSEAPN CMNCQVKFTF TKRRHHCRAC GKVFCGVCCS KKCKLQYMEK EARVCIVCHE
SISKAQAFER MMSPTGSKPN SGITSECSTV QPLRETQPSG SPNTPSPTAS LPISVLKQPS
IEGLCPKEQK RVWFADGILP NGEVADTAKL SSGGKKSSPD ISPVLPDLPT NISPVDHIPS
SVDIKPKNDI AIAGIAEKLQ SPIPIVAAAE EFPITLGTEG LSSPSFILPG EESSISSETE
KSPSPVMVAP SEYNLLSSSS SNYMFLCGID QCVSKEITLI PDDEDELPPL LLAVGERGED
PMVEQCPALG EMMLLLEGEG PHPLTFVLNA NLLVNVKIVS YSSEKCWYFS TNGLHGLGQA
EIVILLLCLP YEDTIPKDIF KLFISIYKDA MKGKYIENLA NITFTESFLN SKDHGGFLFV
TPTFQKLDDL PLPNSPFLCG ILIQKLEIPW AKVFPIRLML RLGAEYGAYP TPITSIRCRK
PLFGEIGHTI MNLLVDLRNY QYTLHNVEQL LIHMEMGKSC IKIPRKRYSD VMKVINSSNE
HVISIGASFS MEADSHLVCV QNEGVYQTQA NSATGHPRKV TGASFVVFNG ALKTSSGFLA
KSSIVEDGLM VQITPETMEG LRQALKEQKD FKITCGKVDA GDLREYVDVC WVENEEKVNK
GVTSWIDGKS LEGIPSERIY QEADFETDEK LVKCTEVFYL LKDQDLSTSA AHYQFAKEIA
IACSAAFCPH VKKLKRHGMN KIGLRVSIDT DKVEFQAGSG GQLLPQRYLN DLDSALIPVI
HGGISNSTCL PIEMELIFFL IENLF
//
