ID F7EU98_ORNAN Unreviewed; 554 AA.
AC F7EU98;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Paraspeckle component 1 {ECO:0000256|ARBA:ARBA00020221};
GN Name=PSPC1 {ECO:0000313|Ensembl:ENSOANP00000014347.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000014347.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000014347.3, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000014347.3,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000014347.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000014347.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus matrix {ECO:0000256|ARBA:ARBA00004109}. Nucleus speckle
CC {ECO:0000256|ARBA:ARBA00004324}. Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the PSPC family.
CC {ECO:0000256|ARBA:ARBA00005922}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F7EU98; -.
DR STRING; 9258.ENSOANP00000014347; -.
DR Ensembl; ENSOANT00000014350.4; ENSOANP00000014347.3; ENSOANG00000009017.4.
DR eggNOG; KOG0115; Eukaryota.
DR GeneTree; ENSGT00940000157358; -.
DR HOGENOM; CLU_027185_2_1_1; -.
DR InParanoid; F7EU98; -.
DR OMA; EQDMRMG; -.
DR OrthoDB; 5403433at2759; -.
DR TreeFam; TF315795; -.
DR Proteomes; UP000002279; Chromosome 20.
DR Bgee; ENSOANG00000009017; Expressed in fibroblast and 8 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR CDD; cd12949; NOPS_PSPC1; 1.
DR CDD; cd12586; RRM1_PSP1; 1.
DR CDD; cd12589; RRM2_PSP1; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR Gene3D; 6.10.250.1170; -; 1.
DR InterPro; IPR012975; NOPS.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR034522; PSP1_RRM1.
DR InterPro; IPR034523; PSP1_RRM2.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR23189:SF14; PARASPECKLE COMPONENT 1; 1.
DR PANTHER; PTHR23189; RNA RECOGNITION MOTIF-CONTAINING; 1.
DR Pfam; PF08075; NOPS; 1.
DR Pfam; PF00076; RRM_1; 2.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 2.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 113..185
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 187..268
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 53..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 467..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 314..382
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 501..523
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 554 AA; 61071 MW; 7F1E26CE7F4E269B CRC64;
MLRGNLKQVR IEKNPARLRA LEAAAAAAAG DGESTTTTAA AAAAAMALAL TAEPAPPPAP
APAPEDRPVE EEGEAAAVAA GAGPGAAAAA AAGFTIDIKS FLKPGEKTYT QRCRLFVGNL
PTDITEEDFK RLFERYGEPS EVFINRDRGF GFIRLESRTL AEIAKAELDG TILKSRPLRI
RFATHGAALT VKNLSPVVSN ELLEQAFSQF GPVEKAVVVV DDRGRATGKG FVEFAAKPPA
RKALERCGDG AFLLTTTPRP VIVEPMEQFD DEDGLPEKLM QKTQQYHKER EQPPRFAQPG
TFEFEYASRW KALDEMEKQQ REQVDRNIRE AKEKLEAEME AARHEHQLML MRQDLMRRQE
ELRRLEELRN QELQKRKQIQ LRHEEEHRRR EEEMIRHREQ EEMRRQQEGF KPNYMENREQ
EMRMGDMGPR GAINMGDAFS PAPAGNQGPP PMMGMNMNNR GTIPGPPLGP GPAMGPDGAA
NLGTPMMPDN GAVHNDRFPQ GPPTQMGSPM GSRTGTETPQ PPMSGVGPVS GGPGGFGRGN
QGGNFEGPNK RRRY
//
