ID F7FIZ1_MACMU Unreviewed; 660 AA.
AC F7FIZ1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Ubiquitin associated and SH3 domain containing A {ECO:0000313|Ensembl:ENSMMUP00000035680.3};
GN Name=UBASH3A {ECO:0000313|Ensembl:ENSMMUP00000035680.3,
GN ECO:0000313|VGNC:VGNC:78687};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000035680.3, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000035680.3}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000035680.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F7FIZ1; -.
DR SMR; F7FIZ1; -.
DR STRING; 9544.ENSMMUP00000035680; -.
DR Ensembl; ENSMMUT00000042672.3; ENSMMUP00000035680.3; ENSMMUG00000018081.4.
DR VEuPathDB; HostDB:ENSMMUG00000018081; -.
DR VGNC; VGNC:78687; UBASH3A.
DR GeneTree; ENSGT00940000160841; -.
DR InParanoid; F7FIZ1; -.
DR OMA; CFCEEQK; -.
DR TreeFam; TF313334; -.
DR Proteomes; UP000006718; Chromosome 3.
DR Bgee; ENSMMUG00000018081; Expressed in spleen and 8 other cell types or tissues.
DR ExpressionAtlas; F7FIZ1; baseline.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0050860; P:negative regulation of T cell receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0001817; P:regulation of cytokine production; IEA:Ensembl.
DR CDD; cd07067; HP_PGM_like; 1.
DR CDD; cd11937; SH3_UBASH3A; 1.
DR CDD; cd14300; UBA_UBS3A_like; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR013078; His_Pase_superF_clade-1.
DR InterPro; IPR029033; His_PPase_superfam.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR035634; UBASH3A_SH3.
DR PANTHER; PTHR16469; UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED; 1.
DR PANTHER; PTHR16469:SF7; UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING PROTEIN A; 1.
DR Pfam; PF00300; His_Phos_1; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50030; UBA; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 15..60
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 275..340
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
SQ SEQUENCE 660 AA; 73964 MW; 35FB43B8DF9B7C0C CRC64;
MAAGETQLYA KVSNKLKGRS TPLLLEPLLA MGFPVHTALK ALAATGRKTA EEALVWLHDH
GNDPSLDDPI PQEYALFLCP TGPLLEKLQE FWRESKRQCA KNRAHEVFPH VTLCDFFTCE
DQRVECLYEA LKRAGDRLLG SFPTAVPLAL HSSISYLGFF VNGSPADIIR EFAMTFATEA
SLLAGTSSSH FWIFSQVPGH GLNLRLNNTS ASFVSHYILQ KYCSVKPCTK QLHLTLAHKF
YPHHQRTLEQ LARAIPLGHS CQWTAALYSR DMRFVHYQTL RALFQYKPQN VDELTLSPGD
YIFVDPTQQD EASEGWVIGI SQRTGCRGFL PENYTDRASE SDTWVKHRMY TFSLATDLNS
RKDSEASSRC SGEFLPQTAR SLSSLQALQA TVARKSVLVV RHGERVDQIF GKSWLQQCST
PDGKYYRPDL NFPCSLPRRS HGIKDFENDP PLSSCGIFQS RIAGDALLDS GIRISSVFAS
PALRCVQTAK LILEELKLEK KIKIRVEPGI FEWTKWEAGK TTPTLMSLEE LKEANFNIDT
DYRPAFPLSA LMPAESYQEY VDRCTASVVQ IVNTCPQDTG VILIVSHGSA LDSCTRPLLG
LPPRECGDFA QLVRKIPSLG MCFCEENKEE GKWELVNPPV KTLTHGANAA FNWRNWMSGN
//
