ID F7FKK9_CALJA Unreviewed; 2832 AA.
AC F7FKK9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=A-kinase anchoring protein 13 {ECO:0000313|Ensembl:ENSCJAP00000023955.4};
GN Name=AKAP13 {ECO:0000313|Ensembl:ENSCJAP00000023955.4};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000023955.4, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000023955.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000023955.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR STRING; 9483.ENSCJAP00000023955; -.
DR Ensembl; ENSCJAT00000025340.5; ENSCJAP00000023955.4; ENSCJAG00000009388.5.
DR eggNOG; KOG3520; Eukaryota.
DR GeneTree; ENSGT00940000154146; -.
DR HOGENOM; CLU_000597_0_0_1; -.
DR InParanoid; F7FKK9; -.
DR TreeFam; TF325887; -.
DR Proteomes; UP000008225; Chromosome 6.
DR Bgee; ENSCJAG00000009388; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd20878; C1_AKAP13; 1.
DR CDD; cd13392; PH_AKAP13; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR13944:SF18; A-KINASE ANCHOR PROTEIN 13; 1.
DR PANTHER; PTHR13944; AGAP007712-PA; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 1811..1858
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 2012..2209
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 2249..2351
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 305..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 466..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 504..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 685..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 800..838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 937..960
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 967..986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1196..1226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1469..1538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1777..1813
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2485..2526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2720..2832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2365..2396
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2589..2700
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 325..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..384
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..441
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..556
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..571
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 816..832
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 937..952
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 968..982
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1469..1496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1779..1810
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2497..2520
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2735..2752
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2763..2788
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2832 AA; 309959 MW; 0F7A35C7DD272465 CRC64;
MKLTPQQAPL YGDCVVTVLL AEEDKVADDV VFYLVFSGST LHHCASTRKV SSDTLETITP
GHDCCETVKV QLCASKEGLP VFVVAEEDFH FIQDEAYDAA QFLATSAGNQ QALNFTRFLD
QSGPPSGDVN SLDKKVVLAF RHLKLPAEWN VLGTDQSLHD AGPRETLMHF AVRLGLLRLT
WFLLQKPGGR GALSIHNQEG ATPVSLALER GYHKLHQLLT EENAGEPDSW SSLSYEIPYG
DCSVRHHREL DIYTLTSESE SQYEHPFPGD SCTGHIFKLM NIQQQLTKTN LKQMDNLKPL
MVTAQDSSGA PQTDGQFLPC APEPMDSQQL SSPEETESSQ CCPGSSVAQT ESPCDLSSIV
EEENTDRSCR KKNKGMERKG EEVGPAPIVD SGTVSDQDSC LQSLPDYGVK GTKRRLSCGN
KNEETGTKSS GMPTDEESLS SGDAVLQRDV VMVPGTAQYS SAGELASIST TDVGTPESAG
EAEHGLMNPD ATVQKNVLQV GESTKDNMGT AGASDMQVTS KPVDKVSVPN CASATSSLGG
NKPAESSLAF SNEETSIEKT AETETSRSCE ESVHAPVEQN SVVLPAAAKD KISDGLEPCT
VLAGIGEATS PSDLALPRLE VDVMPHQNSE INSSHAQSQK GKSSPICSTT GDYKLCSNSA
CQQNTVTSSG ELVAQLCDNI VSQPKSTTAR QPNSQDPPKA THCEDPQANT ITSDPVRDTQ
ERVDFCPFKV VDNEGQGKDV KFDKSLANML EVPSHPHPVV PKMEKELVPD QAVISDSTFF
LANSPGSESV TRDDALSFVP SQKEKGTATP ALHEATDCRD GPDGDANDPD TQPLEDRAAG
LSPCSTVAEL QLVMGNTSLT RLGGEHEGPA PSAAPEVLSI KGDTDSSLQN AGKATLALDS
VLTEEGKILV VSESSGAQEQ DKDKAVTSSS IMENALSSGT LQEEQGTPSP EQETPRFHEK
SISAASAKDE ALQLSNSPGA PSAYLKAETE HNKEVAPQVS LLTQGWAFQS LVLPGTSLGT
NSRQEALGAE QNSSTLLQCL LPDGCDWSEA LNYSQPSPLD DEVKNTKCQG KPNISSCEVS
GNVTMDITGF NDVQDTAEPR RKSVSHNTQD ILIPNVSSSQ EKKVILGLPV ALQDKAVTDP
QGFGTPEMVP LDWVKGKLEG ADHSCNTGDS EEARIDNEAH PVLLQPAAKE LPTKMGLSAH
HDGTPAGKRE VMRGPPSDRG RSTPSLPCLV SAQAAPLPKG VDLIEEAASR IVDAVIQGVK
AAGALLTEEK ACHVSASSAE LDPLTEGLEN ASTEKVSAFS PGESLPVGST HEEATGSLGG
CFAGGEEPEK IILPVRGPEA ATEMPDVKAE DEVDFLSNTR ASSVSEEVAV WSVPATPKTK
QGPVAQAINR ESWCTIDPCP DAASLLASKQ SPECENFLDV GLGRECTSKQ GVLKRESEND
SALFHSCSDE MDSIIFPKPE EEQLVCDITG SSSSTDDTAS LDRHSSHGSD ASLSHISKPS
KSRDRQSLDG FYSHGMGAEG RESESEPVGP GDMEEEEMDS ITEVPANCSV LRSSMRSLSP
FRRHSWGPGK NAANDAEMNH RSSMRVLGDV VRRPPIHRRS MSWCPPGVQY SAGLSADFNN
RSFSLEGLTG GAGIGTKPSS SLEVGSVNAK ELRHPFSGEE RGDSLVSLSE EDLESDHREH
RIFDQQICHR SKQQGFNYCT SAISSPLTKS ISLMTISHPG LDNSRPFHST FHNTSANVTE
SITEENYNFL PQCPSKKDFE GKSGTKVSRT FSYIKNKMSS SKKSKEKEKE KIKEKEKDSK
DKEKDKKTLN GHSFSSIPVV GPISCSQCTK PFTNKDAYTC ANCGAFVHKG CRESLASCAK
VKMKQPRGNL QAQDTSSLPT VIMRNKPSQP KERPRSAVLL VDETTTTQIF ANRRSQQSVS
LSKSVSIQNI TGVGNDENMS NTWKFLSHST DSLNKISKVN ESTESLTDEG TDMNEGQLLG
DFEMDSKQLE AESWSRIIDS KFLKQQKKDV VKRQEVIYEL MQTELHHVRT LKIMSDVYSR
GMMTDLLFEQ QMVEKLFPCL DELIGIHSQF FQRILERKKE SLVDESEKNF LIKRIGDVLV
NQFSSENAER LKKTYGKFCG QHNQSVNYFK DLYTKDKRFQ AFVKKKMSSS VVRRLGIPEC
ILLVTQRITK YPVLFQRILQ CTKDDEVEQE DLAQSLSLVK EVIGAVDSKV ASYEKKVRLN
EIYTKTDSKS IMRMKSGQMF AKEDLKRKKL IRDGSVFLKS AAGRLKEVQA VLLTDILVFL
QEKDQKYIFA SLDQKSTVIS LKKLIVREVA HEEKGLFLIS MGMKDPEMVE VHASSKEERN
SWIQIIQDTI NMLNRDEDEG IPSENEEEKK MLDTKARELK EQLQQKDQQI LLLLEEKEMI
FRDMAECSTP LPEDCSPKHS PRVLFRSHTE EALKGGPLMK SAINEVEILQ GLVSGSLGGT
LGQTVSSPVE QEGVVGPVSL PRRAETFGGF DSHQMNASKG GEKEEGDDGQ DLRRTESDSG
LKKGGNGNLV FMLKRNSEQV VQSIVHLHEL LSTLQGVVLQ QDSYIEDQKL VLSERALTRS
LSRPSSLVEQ EKQRSLEKQR QDLANLQKQQ AQYLEEKRRR EREWEARERE LREREALLAQ
REEKVQQGQQ DLEKEREELQ QKKGTYQYDL ERLRAAQKQL EREQEQLHRE AERLGQRQAE
RDLCQVSHPH TKLMRIPSFF PSAEEPPLPS APSIAKSGSL DSELSVSPKR NSISWTHKDK
GPFHILSSTS QTNKGSEGQS QAPAPTSAST RLFGLAKPKE KKEKKKKNKT SRSQPGDGPT
SEVSAEGEEI FC
//
