ID F7FQA6_CALJA Unreviewed; 524 AA.
AC F7FQA6;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 4.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Cdc42 guanine nucleotide exchange factor 9 {ECO:0000313|Ensembl:ENSCJAP00000036229.4};
GN Name=ARHGEF9 {ECO:0000313|Ensembl:ENSCJAP00000036229.4};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000036229.4, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000036229.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000036229.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F7FQA6; -.
DR Ensembl; ENSCJAT00000038262.4; ENSCJAP00000036229.4; ENSCJAG00000019494.5.
DR eggNOG; KOG3519; Eukaryota.
DR GeneTree; ENSGT00940000154103; -.
DR HOGENOM; CLU_008436_2_0_1; -.
DR TreeFam; TF316832; -.
DR Proteomes; UP000008225; Chromosome X.
DR Bgee; ENSCJAG00000019494; Expressed in frontal cortex and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd01224; PH_Collybistin_ASEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR47544; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR PANTHER; PTHR47544:SF2; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..46
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 82..266
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 297..404
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 524 AA; 62000 MW; EDB651D7C9A2A71B CRC64;
MANRELAFKA GDVIKVLDAS NKDWWWGQID DEEGWFPASF VRLWVNQEDE VEEGPSDVQN
GHLDPNSDCL CLGRPLQNRD QMRANVINEI MSTERHYIKH LKDICEGYLK QCRKRRDMFS
DEQLKIIFGN IEDIYRFQMG FVRDLEKQYN NDDPHLSEIG PCFLEHQDGF WIYSEYCNNH
LDACMELSKL MKDSRYQHFF EACRLLQQMI DIAIDGFLLT PVQKICKYPL QLAELLKYTA
QDHSDYRYVA AALAVMRNVT QQINERKRRL ENIDKIAQWQ ASVLDWEGED ILDRSSELIY
TGEMAWIYQP YGRNQQRVFF LFDHQMVLCK KDLIRRDILY YKGRIDMDKY EVVDIEDGRD
DDFNVSMKNA FKLHNKETEE IHLFFAKKLE EKIRWLRAFR EERKMVQEDE KIGFEISENQ
KRQAAMTVRK VPKQKGVNSA RSVPPSYPPP QDPLNHGQYL VPDGIAQSQV FEFTEPKRSQ
SPFWQNFSRR APDLYKTVVM KPAKMADWKQ LLCAAVTDRR KSGE
//
