ID F7G2U6_ORNAN Unreviewed; 661 AA.
AC F7G2U6;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Fibronectin type-III domain-containing protein {ECO:0000259|PROSITE:PS50853};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000002059.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000002059.2, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000002059.2,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000002059.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000002059.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F7G2U6; -.
DR STRING; 9258.ENSOANP00000002059; -.
DR Ensembl; ENSOANT00000002060.2; ENSOANP00000002059.2; ENSOANG00000001288.3.
DR eggNOG; ENOG502S2KP; Eukaryota.
DR GeneTree; ENSGT00390000012431; -.
DR HOGENOM; CLU_031440_0_0_1; -.
DR InParanoid; F7G2U6; -.
DR OMA; ECSWEYE; -.
DR TreeFam; TF338613; -.
DR Proteomes; UP000002279; Chromosome X1.
DR Bgee; ENSOANG00000001288; Expressed in liver and 2 other cell types or tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0019955; F:cytokine binding; IBA:GO_Central.
DR GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF51; INTERLEUKIN-12 RECEPTOR SUBUNIT BETA-1; 1.
DR Pfam; PF00041; fn3; 1.
DR SMART; SM00060; FN3; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR PROSITE; PS50853; FN3; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 520..543
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 108..201
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 418..514
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 621..661
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 661 AA; 74753 MW; 37D6D7731F8D1289 CRC64;
MPFQGEETVS DGGPWDLLCY KVFPDGYECS WKYVGASANV THFLRCCFGT GSCCYFKTGN
AHSITFSDQD KVPVFQNVTF WVESHSGNSI QKSQNITVLL FSSVKFDPPS EDIHFSKSNG
MLIIKWKTPE KQENAVTEYR YRMRNASWEK GDCGIQEDPD LETCNIHLEK DVACEFQIRR
QKNAHGGHWS NWSKSICIPA EIRRSPEVNY TVGKLENNGT RKLFLSWEKL NPELPEGCRN
PGSRMEVNYT LVVHMLSCQC QQKAEKRMKP KTTLTISGAA YNFSVGTLNT IGPGPNQTYH
VPPDAQTEIR SPSVNFSGGI ILLKHEVKSY CIEWYPQAAD WTNATCALKS ISEEKIPVAT
SNSREARVRH SRTNASGNME PGKCYRITVY SSDRPKSLMS WSTLFSTYHF SRDVSKAGPS
QIKITNITVD SVSLEWKPSP LSQCPGILKE YVIDCTDEEN NKTRYFPVNA SLLQYTLQNL
NPNTFYRIQI RGDTATEKGA WSQPQRFQIH TTDKKQMDGY FFLVCLGIFG FIVVTGILGY
FGVKRVKKHL CPPVPDPLAS DATKFPESEL KLARQWTRIP DQCEEAGPGE PLVVEACLDT
GEADVNQETG VLYMHDKTQE MRETADTKEV RTGSEEEAPL ETDLPFEYRR QMQGEPEVED
L
//
