ID F7GCP0_ORNAN Unreviewed; 930 AA.
AC F7GCP0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=NLR family pyrin domain containing 12 {ECO:0000313|Ensembl:ENSOANP00000014644.3};
GN Name=NLRP12 {ECO:0000313|Ensembl:ENSOANP00000014644.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000014644.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000014644.3, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000014644.3,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000014644.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000014644.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR AlphaFoldDB; F7GCP0; -.
DR STRING; 9258.ENSOANP00000014644; -.
DR Ensembl; ENSOANT00000014647.3; ENSOANP00000014644.3; ENSOANG00000009200.4.
DR eggNOG; ENOG502QS9E; Eukaryota.
DR GeneTree; ENSGT00940000160873; -.
DR HOGENOM; CLU_002274_2_0_1; -.
DR Proteomes; UP000002279; Chromosome 10.
DR Bgee; ENSOANG00000009200; Expressed in testis and 2 other cell types or tissues.
DR CDD; cd00116; LRR_RI; 1.
DR CDD; cd08320; Pyrin_NALPs; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF11; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF13516; LRR_6; 3.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM01288; FISNA; 1.
DR SMART; SM00368; LRR_RI; 7.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT DOMAIN 3..95
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 202..519
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REGION 159..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 930 AA; 103631 MW; 3AA8B070329F43D0 CRC64;
ALLTSGLSGP RLAEYLEELR DPELRKFKFH LEDLAPAAGW APIPWGRTEK ADSLDLAHLL
VAHVGERGAW ELAVHVFERI HRKDLWERAR AEAEVRDCEL VVGRECVCLL YSPEHPRDVY
REHIRRKFRF FEDRNARPGE CVNLSQRYTQ LLLMERHPTP RDAAPVSPTP QREDAGAPER
QPGPLQLETL LEPDASWPEP PRTVVLRGAA GIGKSMLARK IMLDWADGLL YRARFDYLFY
VSCREMSRVG RGSLAGLISG RWPRREAPLA DILRRPERLL FVIDGFDELG RTPRRPPPGR
RAGGWKAKMP VAGLLGGLLG KDLLPEASLL ITTRPAALAR LQPLLEQPRH AEILGFSRAG
RRDYFRKFFG DGRQASRALG LVRDVEALSA VCFVPLVCWI VCTCLKQEME RGEPPGQPSK
TTTAVYVFYL LSLLRPDPGG SGPRGRPVLA PLCSLAAHGV WARKVLFDEG DLSRHGLAGS
DVSAFLNLSV FQKDIHCQRL YSFVHRSFQE FFAALFYLTD EGGREGGRGS RHSVTRLLEH
YGRSETGYLA LTVRFLFGLL NGENKSYLER QLGCPLSPTV KGELLAWIEA GARIGGRTLE
RGALDLFSCL YETQEEGFIR RALDPFQVIV ACDLSTKMDH VISAFCVGNC RNASVVHLGS
EEERVRCWLP DTYCEHLSSA LRTNQNLAEL VLDRNALGNR GVKLLCQGLG HANCKLQNLG
LKKCRFSSAA CQDISSALSA NQNLVMMDLS NNALEDVGVK LLCAGLRHPK CRLQSLQLKK
CYFSWAACED LSSVLSTNPH LMELDLTGNA LGDAGVQLLC VGMKQTSCRL KTLWLKICHL
TRASCMELAS VLSVDCSLTE LDLSLNDLED AGVRLLCEGL GQPKCKLQKL RYTRCFLLKS
LLRGMGITII IKIVVFVKPL LFLDCEPVVG
//
