ID F7GNY9_MACMU Unreviewed; 647 AA.
AC F7GNY9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=FAST kinase domain-containing protein 4 {ECO:0000256|ARBA:ARBA00040471};
DE AltName: Full=Protein TBRG4 {ECO:0000256|ARBA:ARBA00043220};
DE AltName: Full=Transforming growth factor beta regulator 4 {ECO:0000256|ARBA:ARBA00042265};
GN Name=TBRG4 {ECO:0000313|Ensembl:ENSMMUP00000014190.4,
GN ECO:0000313|VGNC:VGNC:78151};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000014190.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000014190.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000014190.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC {ECO:0000256|ARBA:ARBA00004305}.
CC -!- SIMILARITY: Belongs to the FAST kinase family.
CC {ECO:0000256|ARBA:ARBA00038281}.
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DR STRING; 9544.ENSMMUP00000066807; -.
DR Ensembl; ENSMMUT00000015141.4; ENSMMUP00000014190.4; ENSMMUG00000010823.4.
DR Ensembl; ENSMMUT00000100274.1; ENSMMUP00000066807.1; ENSMMUG00000010823.4.
DR VEuPathDB; HostDB:ENSMMUG00000010823; -.
DR VGNC; VGNC:78151; TBRG4.
DR GeneTree; ENSGT01030000234607; -.
DR HOGENOM; CLU_029448_0_0_1; -.
DR OMA; NFNHSQV; -.
DR OrthoDB; 5347066at2759; -.
DR TreeFam; TF324885; -.
DR Proteomes; UP000006718; Chromosome 3.
DR Bgee; ENSMMUG00000010823; Expressed in skeletal muscle tissue and 21 other cell types or tissues.
DR GO; GO:0005759; C:mitochondrial matrix; IBA:GO_Central.
DR GO; GO:0035770; C:ribonucleoprotein granule; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0090615; P:mitochondrial mRNA processing; IEA:Ensembl.
DR GO; GO:0000963; P:mitochondrial RNA processing; IBA:GO_Central.
DR GO; GO:0044528; P:regulation of mitochondrial mRNA stability; IBA:GO_Central.
DR InterPro; IPR013579; FAST_2.
DR InterPro; IPR010622; FAST_Leu-rich.
DR InterPro; IPR013584; RAP.
DR PANTHER; PTHR21228:SF59; FAST KINASE DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR21228; FAST LEU-RICH DOMAIN-CONTAINING; 1.
DR Pfam; PF06743; FAST_1; 1.
DR Pfam; PF08368; FAST_2; 1.
DR Pfam; PF08373; RAP; 1.
DR SMART; SM00952; RAP; 1.
DR PROSITE; PS51286; RAP; 1.
PE 3: Inferred from homology;
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 577..635
FT /note="RAP"
FT /evidence="ECO:0000259|PROSITE:PS51286"
SQ SEQUENCE 647 AA; 72984 MW; 91F277777E4F36BA CRC64;
MAAHLVKRCT CLLREAARQA PVMAPVGRLR LARVAHKTLT SSATSPISHF PGSLVELVEK
EQAFTPYIEN QVDRLIKKAA RPEELLELLG GSHHLDNNHA ALVLIRLSHL LSEKPKDKAL
LIQDARFQQL LCLLNSQINL VWHGTLSRLL RSLYALGLPR TSKELQSVEQ EVRWRMRKLK
YKHLAFLADS CATLSQEQHS QELLTELLMH LERRWTEIED GRTLVTIMMK VGHLSEPLMN
RLEDKHSLEK RAWQAAPKVT QCLELVEQFG PDELRKVLVT LAAQSRRSVP LLRAISYHLV
QKPFSLTKSV LLDLAYAYGK LGFHQTQVSQ RLAADLLSLM PSLTSGEVAR CAKSFALLKW
LNLPLYEAFA QHVLNRAQDI TVPHLCSVLL AFARLNFHPD QEDEFFSLVH EKLGSELPGL
EPALQVDLVW ALCVLQQARE AELQAVLHPE FHIQFLGGKS QKDQNTFQKL LHINATAMLE
HPEYSGPLLP ASAVAPRPSA LDRKVTPLQK ELQETLKGLL GSADRGSLEV ATQYGWVLDA
EVLLDSDGQF LPVRDFVAPH LAQPTGSQPP PAGAKRLAFL RWEFPNFSTR SKDLLGRFVL
ARRHILAAGF LIVDVPFYEW LELKSEWQKG AYLKDKMRKA VAEELAK
//
