ID F7H4I3_CALJA Unreviewed; 473 AA.
AC F7H4I3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Hematopoietic cell-specific Lyn substrate 1 {ECO:0000313|Ensembl:ENSCJAP00000015637.2};
DE SubName: Full=Hematopoietic lineage cell-specific protein {ECO:0000313|EMBL:JAB30524.1};
GN Name=HCLS1 {ECO:0000313|EMBL:JAB30524.1,
GN ECO:0000313|Ensembl:ENSCJAP00000015637.2};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000015637.2, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000015637.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB30524.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Cerebellum {ECO:0000313|EMBL:JAB45995.1}, and Cerebral cortex
RC {ECO:0000313|EMBL:JAB30524.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
RN [3] {ECO:0000313|Ensembl:ENSCJAP00000015637.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; GAMR01003408; JAB30524.1; -; mRNA.
DR EMBL; GAMP01006760; JAB45995.1; -; mRNA.
DR RefSeq; XP_002758801.1; XM_002758755.3.
DR STRING; 9483.ENSCJAP00000015637; -.
DR Ensembl; ENSCJAT00000016523.4; ENSCJAP00000015637.2; ENSCJAG00000008451.4.
DR GeneID; 100411356; -.
DR KEGG; cjc:100411356; -.
DR CTD; 3059; -.
DR GeneTree; ENSGT00940000158997; -.
DR HOGENOM; CLU_019379_2_0_1; -.
DR OMA; RCRGHFG; -.
DR OrthoDB; 101008at2759; -.
DR Proteomes; UP000008225; Chromosome 15.
DR Bgee; ENSCJAG00000008451; Expressed in kidney and 6 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0017124; F:SH3 domain binding; IEA:Ensembl.
DR GO; GO:0035591; F:signaling adaptor activity; IEA:Ensembl.
DR GO; GO:0007015; P:actin filament organization; IEA:Ensembl.
DR GO; GO:0030218; P:erythrocyte differentiation; IEA:Ensembl.
DR GO; GO:0038158; P:granulocyte colony-stimulating factor signaling pathway; IEA:Ensembl.
DR GO; GO:2000107; P:negative regulation of leukocyte apoptotic process; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0051169; P:nuclear transport; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0030854; P:positive regulation of granulocyte differentiation; IEA:Ensembl.
DR GO; GO:0045651; P:positive regulation of macrophage differentiation; IEA:Ensembl.
DR GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0042307; P:positive regulation of protein import into nucleus; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
DR GO; GO:0030833; P:regulation of actin filament polymerization; IEA:Ensembl.
DR GO; GO:0009725; P:response to hormone; IEA:Ensembl.
DR CDD; cd12073; SH3_HS1; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR003134; Hs1_Cortactin.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10829; CORTACTIN AND DREBRIN; 1.
DR PANTHER; PTHR10829:SF5; HEMATOPOIETIC LINEAGE CELL-SPECIFIC PROTEIN; 1.
DR Pfam; PF02218; HS1_rep; 4.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51090; CORTACTIN; 4.
DR PROSITE; PS50002; SH3; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 415..473
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 243..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..271
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..395
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 473 AA; 52527 MW; 37599AF40A7071D3 CRC64;
MWKSVVGHDV SVSVETQGDD WDTDPDFVND ISEKEQRWGA KTIEGSGRTE HINIHQLRNK
VSEEHDVLKK KEMESGPKAS HGYGGRFGVE RDRMDKSAVG HEYIAEVEKH SSQTDAAKGF
GGKYGVERDR ADKSAVGFDY KGEVEKHTSQ KDYSRGFGGR YGVEKDKRDK AALGYDYKGE
TEKHESQRDY AKGFGGQYGI QKDRVDKSAV GFNEMEAPTT AYKKTTPIEA ASSGARGLKA
KFESMAEEKR KREEEEKAQQ VARRQQERKA VVKMSPEAPQ LGVAIEEPAV PVSLPKKISS
EAWPPAGTPS SSEPKPVITS RENPVPLLPM RLTLSEDNEE PPALPPRTPE GLQVEEEPVY
EAEPEPEPEN DYEDVGDMDR HEQEDEAEGD YEEVLEPEGS FSSTLAGSSG YPDGGLGISA
VALYDYQGEG SDELSFDPDD VITDIEMVDE GWWRGRCHGH FGLFPANYVK LLE
//
