ID F7H543_CALJA Unreviewed; 725 AA.
AC F7H543;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 2.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Actin filament-associated protein 1-like 1 {ECO:0000256|ARBA:ARBA00016930};
GN Name=AFAP1L1 {ECO:0000313|Ensembl:ENSCJAP00000039370.3};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000039370.3, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000039370.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000039370.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May be involved in podosome and invadosome formation.
CC {ECO:0000256|ARBA:ARBA00002089}.
CC -!- SUBCELLULAR LOCATION: Cell projection, invadopodium
CC {ECO:0000256|ARBA:ARBA00004264}. Cell projection, podosome
CC {ECO:0000256|ARBA:ARBA00004188}. Cytoplasm
CC {ECO:0000256|ARBA:ARBA00004496}.
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DR AlphaFoldDB; F7H543; -.
DR Ensembl; ENSCJAT00000041592.4; ENSCJAP00000039370.3; ENSCJAG00000021140.5.
DR GeneTree; ENSGT00950000183067; -.
DR HOGENOM; CLU_014418_1_0_1; -.
DR Proteomes; UP000008225; Chromosome 2.
DR Bgee; ENSCJAG00000021140; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0002102; C:podosome; IEA:UniProtKB-SubCell.
DR CDD; cd13306; PH1_AFAP; 1.
DR CDD; cd13307; PH2_AFAP; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR030113; AFAP.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR14338; ACTIN FILAMENT-ASSOCIATED PROTEIN 1 FAMILY MEMBER; 1.
DR PANTHER; PTHR14338:SF1; ACTIN FILAMENT-ASSOCIATED PROTEIN 1-LIKE 1; 1.
DR Pfam; PF00169; PH; 2.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT DOMAIN 220..316
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 418..512
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 82..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 173..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 566..604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 704..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 612..689
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 111..125
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 583..598
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 725 AA; 81723 MW; DC46ED91A9312BFC CRC64;
MDRGRVLEQL LPELTGLLSL LDHEYLSDTA LEKKMAVASI LQSLQPLPAK EVSYLYVNTA
DLHSGPSFVE SLFEEFDCDL SDLQNMPEDE GEPSKGASPE PAKSPCLRNA ADLPPPLPNK
PPPEDYYEEA LPLGPGKSPE YISSHNGYSP AHSIVDGYYE DADSSYPATR VNGELKSSYN
DSDAMSSSYE SYDEEEEEGK SPQPRHQWPS EEASMHLVKE CRICAFLLRK KRFGQWAKQL
TVIREDQLLC YKSSKDRQPH LRLALDACSV IYVPKDSRHK RHELRFTQGA TEVLVLALQS
REQAEEWLKV IREVSKPVGG AEAVEVPRSP VLLCKLDLDK RLSQEKQTSD SDSVGIGDNC
SSLGRREACD HGKGKKSSLA ELKGSMSRAA GRKITRIINF SKKKQLADDL QTSSAEEEVP
CCGYLNVLVN QGWKERWCRL KCNTLYFHKD HTDLQTHVNA IALQGCEVAP GFGPRHPFAF
RILRNRQEVA ILEASCSEDM GRWLGLLLVE MGSRVTPEAL HYDYVDVETL TSIVSAGRNS
FLYARSCQNQ WPEPRVYDDV PYEKMQDEEP ERPTGAQVKR HASSCSEKSH RVDPQVKVKR
HASSANQYKY GKNRAEEDAR RYLLEKEKLE KEKETIRTEL MALRQEKREL KEAIRSSPGA
KLKALEEAVA TLEAECRAKE ERRIDLELKL VAVKERLQQS LAGGPALGLS MSSKPKSVEW
EMKKT
//
