ID F7HEZ7_MACMU Unreviewed; 716 AA.
AC F7HEZ7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Tensin 4 {ECO:0000313|Ensembl:ENSMMUP00000012289.4};
GN Name=TNS4 {ECO:0000313|Ensembl:ENSMMUP00000012289.4,
GN ECO:0000313|VGNC:VGNC:79432};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000012289.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000012289.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000012289.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}.
CC -!- SIMILARITY: Belongs to the PTEN phosphatase protein family.
CC {ECO:0000256|ARBA:ARBA00007881}.
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DR AlphaFoldDB; F7HEZ7; -.
DR SMR; F7HEZ7; -.
DR STRING; 9544.ENSMMUP00000012289; -.
DR PaxDb; 9544-ENSMMUP00000012289; -.
DR Ensembl; ENSMMUT00000013111.4; ENSMMUP00000012289.4; ENSMMUG00000009386.4.
DR VEuPathDB; HostDB:ENSMMUG00000009386; -.
DR VGNC; VGNC:79432; TNS4.
DR eggNOG; KOG1930; Eukaryota.
DR GeneTree; ENSGT00940000160142; -.
DR HOGENOM; CLU_398985_0_0_1; -.
DR InParanoid; F7HEZ7; -.
DR OMA; SQPSMKF; -.
DR OrthoDB; 3439226at2759; -.
DR TreeFam; TF315996; -.
DR Proteomes; UP000006718; Chromosome 16.
DR Bgee; ENSMMUG00000009386; Expressed in olfactory segment of nasal mucosa and 4 other cell types or tissues.
DR GO; GO:0005925; C:focal adhesion; IBA:GO_Central.
DR GO; GO:0008104; P:protein localization; IEA:Ensembl.
DR CDD; cd01213; PTB_tensin; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR013625; PTB.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR033929; Tensin_PTB.
DR PANTHER; PTHR45734; TENSIN; 1.
DR PANTHER; PTHR45734:SF6; TENSIN-4; 1.
DR Pfam; PF08416; PTB; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 450..557
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 121..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 156..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..340
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..426
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 716 AA; 77065 MW; 690FE57B4D1263A2 CRC64;
MSQVMSSPLL AGGHAVSLAP CDEPRRTLHP APSPSLPPQC SYYTTEGWGA QALMAPVPCM
GPPDRLQQAP QAQAKATCFL PSPGEQALGT PEDLDSYIDF SLESLNQMIL ELDPTFQLLP
QGTGGPRAEP AQSTMSVRKK EEPEALDIKY IEVTSARSRC HDGPQRCSSP SVTPPFGSPR
SGGLLLSRDV PRETRSSSES LIFSGNQGRG HQRPLPPSEG LSPQPPNSPS ISIPCMGSKA
LSPHGLGSPL VASPRLEKRL GGLAPQRASR ISVLSASPAS DVSYMFGSSQ SLLHSSNSSH
QSSSRSLESP ASSSSSLHSL GSVSLCTRPS DFQAPRNPTL TMGQPRAPHC PPLAKEHASS
CPPSITNSMV DIPIVLINGC PEPGSSPPQW SPGHQSSVRP GAASPSNQVC PGTRSHSQTL
SDAPFTTCPE GPTRDMQPTM KFVMDTSKYW FKPNITREQA IELLRKEEPG AFVIRDSSSY
RGSFGLALKV KEVPPSAQNR PGEDSNDLIR HFLIESSAKG VHLKGADEEP YFGTLSAFVC
QHSIMALALP CKLTIPQREL GGADGASDST DSPASCQRKS AGCHTLYLSS VSVETLTGAL
AVQKAISTTF ERDVLPTPTV VHFKVTEQGI TLTDVQRKVF FRRHYPLTTL RFCGMDPEQR
KWQKYCKPSW IFGFVAKSQT EPQENVCHLF AEYDTVQPAS QVISLVTALL QDVERM
//
