ID F7HIJ2_MACMU Unreviewed; 369 AA.
AC F7HIJ2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=V-set and immunoglobulin domain containing 4 {ECO:0000313|Ensembl:ENSMMUP00000003690.4};
GN Name=VSIG4 {ECO:0000313|Ensembl:ENSMMUP00000003690.4,
GN ECO:0000313|VGNC:VGNC:79062};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000003690.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000003690.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000003690.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_014983079.1; XM_015127593.1.
DR AlphaFoldDB; F7HIJ2; -.
DR SMR; F7HIJ2; -.
DR Ensembl; ENSMMUT00000003906.4; ENSMMUP00000003690.4; ENSMMUG00000002750.4.
DR GeneID; 709685; -.
DR CTD; 11326; -.
DR VEuPathDB; HostDB:ENSMMUG00000002750; -.
DR VGNC; VGNC:79062; VSIG4.
DR eggNOG; ENOG502S07Y; Eukaryota.
DR GeneTree; ENSGT00390000001432; -.
DR OrthoDB; 3808804at2759; -.
DR TreeFam; TF336175; -.
DR Proteomes; UP000006718; Chromosome X.
DR Bgee; ENSMMUG00000002750; Expressed in ileum and 20 other cell types or tissues.
DR ExpressionAtlas; F7HIJ2; baseline.
DR GO; GO:0032703; P:negative regulation of interleukin-2 production; IEA:InterPro.
DR GO; GO:0043031; P:negative regulation of macrophage activation; IEA:InterPro.
DR GO; GO:0042130; P:negative regulation of T cell proliferation; IEA:InterPro.
DR CDD; cd16082; IgC_CRIg; 1.
DR CDD; cd16089; IgV_CRIg; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR039939; VSIG4.
DR InterPro; IPR039944; VSIG4_IgV.
DR PANTHER; PTHR15466; V-SET AND IMMUNOGLOBULIN DOMAIN CONTAINING 4; 1.
DR PANTHER; PTHR15466:SF2; V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..369
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023857150"
FT DOMAIN 26..136
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 148..231
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 369 AA; 40451 MW; EB8B78C62CE67697 CRC64;
MALAVMGILL GLLLLGHLTV DTYGRPILEV PESITGPWKG DVNIPCTYGP LQGYTQVLVK
WLVQRGSDPV TIFLRDSSGD HIQQAKYQGR LHVNQKVPGD VSLQLSTLEM DDQSHYTCEV
TWQTPDGNQV VRDKITELRV QKLSVSKPTV TTGSGYGFTV PQGMRISLQC QARGSPPISY
IWYKEQTNNQ EPIKVATLST LLFKPAMVAD SGSYFCAAKG RVGSEQRSDI VKFVVKDSSK
LLKTKTEAPT TMRHPLKATS TVKQSWDWTT DVDGYLGATS AGPEHVYEAA RVHAREANDS
GDTMRVAIFA SGCPSDEPAS QNLGNNYSDE PCIGQEYQII AQINGDYAHL LDTVPLDYEF
LATEGKTAC
//
