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Database: UniProt
Entry: F7HTP7_CALJA
LinkDB: F7HTP7_CALJA
Original site: F7HTP7_CALJA 
ID   F7HTP7_CALJA            Unreviewed;      2161 AA.
AC   F7HTP7;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   27-SEP-2017, entry version 38.
DE   RecName: Full=Voltage-dependent R-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1E {ECO:0000313|Ensembl:ENSCJAP00000008352};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000008352, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000008352, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000008352}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1E
CC       gives rise to R-type calcium currents. R-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA).
CC       They are however insensitive to dihydropyridines (DHP), omega-
CC       conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega-
CC       Aga-IVA). Calcium channels containing alpha-1E subunit could be
CC       involved in the modulation of firing patterns of neurons which is
CC       important for information processing.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCJAP00000008352}.
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DR   EMBL; ACFV01050711; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01050712; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01050713; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01050714; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01050715; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01050716; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01050717; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01050718; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01050719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01050720; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCJAT00000008831; ENSCJAP00000008352; ENSCJAG00000004426.
DR   eggNOG; ENOG410INF5; Eukaryota.
DR   eggNOG; ENOG410YD06; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   Proteomes; UP000008225; Chromosome 18.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005449; VDCC_R_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF253; PTHR10037:SF253; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01633; RVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     59     81       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    133    154       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    166    188       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    316    336       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    342    361       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    449    471       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    526    549       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    998   1017       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1070   1089       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1135   1157       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1247   1272       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1328   1346       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1358   1381       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1387   1405       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1452   1470       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1547   1571       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1587   1622       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      545    572       {ECO:0000256|SAM:Coils}.
FT   COILED      945    967       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2161 AA;  244944 MW;  B02459A8B38BAC40 CRC64;
     MDFIVVLSGI LATAGTHFNT HVDLRTLRAV RVLRPLKLVS GIPSLQIVLK SIMKAMVPLL
     QIGLLLFFAI LMFAIIGLEF YSGKLHRACF MNNSGILEGF DPPHPCGVQG CPAGYECKDW
     IGPNDGITQF DNILFAVLTV FQCITMEGWT TVLYNTNDAL GATWNWLYFI PLIIIGSFFV
     LNLVLGVLSG EFAKERERVE NRRAFMKLRR QQQIERELNG YRAWIDKAEE VMLAEENKNA
     GTSALEVVLR RATIKRSRTE AMTRDSSDEH CVDISSVGTP LARASIKSTK VDGVSYFRHK
     ERLLRISIRH MVKSQVFYWI VLSLVALNTA CVAIVHHNQP QWLTHLLYYA EFLFLGLFLL
     EMSLKMYGMG PRLYFHSSFN CFDFGLKIGI IMSQWAVSFE VVWAIFRPGT SFGISVLRAL
     RLLRIFKITK YWASLRNLVV SLMSSMKSII SLLFLLFLFI VVFALLGMQL FGGRFNFNDG
     TPSANFDTFP AAIMTVFQIL TGEDWNEVMY NGIRSQGGVS SGMWSAIYFI VLTLFGNYTL
     LNVFLAIAVD NLANAQELTK DEQEEEEAFN QKHALQKAKE VSPMSAPNMP SIERDRRRRH
     HMSMWEPRSS HLRERRRRHH MSVWEQRTSQ LRKHMQMSSQ EALNREEAPP MNPLNPLNPL
     SPLNPLNAHP SLYRRPRAIE GLALGLALEK FDEERISRGG SLKGEGGDRS STLDNQRTPL
     SLGQRELPWL PRSCHGNCDP TQQEAGGGEA VVTFEDRARH RQSQRRSRHR RVRTEGKESS
     SASRSRSASQ ERSLDEAVPA EGEKEHELRG NHSAKEPTIQ EERAQDLRRT NSLMLSRGSG
     LAGALDEANT PLVLPHPELE VGKDAVLTEQ EPEGSSEQAL LGDVQLDMGR VISHSEPDLS
     CITANTDKAI TESTSVTVAI PDVGPLVDST VVHISNKTDG EASPLKEAEI RDDEEEVENK
     KQKKEKRETG KAMVPHSSMF IFSTTNPIRR ACHYIVNLRY FEMCILLVIA ASSIALAAED
     PVLTNSERNK VLRYFDYVFT GVFTFEMVIK MIDQGLILQD GSYFRDLWNI LDFVVVVGAL
     VAFALANALG TNKGRDIKTI KSLRVLRVLR PLKTIKRLPK LKAVFDCVVT SLKNVFNILI
     VYKLFMFIFA VIAVQLFKGK FFYCTDSSKD TEKECIGNYV DHEKNKMEVK GREWKRHEFH
     YDNIIWALLT LFTVSTGEGW PQVLQHSVDV TEEDRGPSRS NRMEMSIFYV VYFVVFPFFF
     VNIFVALIII TFQEQGDKMM EECSLEKNER ACIDFAISAK PLTRYMPQNR HTFQYRVWHF
     VVSPSFEYTI MAMIALNTVV LMMKYYSAPC TYELALKYLN IAFTMVFSLE CVLKVIAFGF
     LNYFRDTWNI FDFITVIGSI TEIILTDSKL VNTSGFNMSF LKLFRAARLI KLLRQGYTIR
     ILLWTFVQSF KALPYVCLLI AMLFFIYAII GMQVFGNIKL DEESHINRHN NFRSFFGSLM
     LLFRLRSATG EAWQEIMLSC LGEKGCEPDT TAPSGQNENE RCGTDLAYVY FVSFIFFCSF
     LMLNLFVAVI MDNFEYLTRD SSILGPHHLD EFVRVWAEYD RAACGRIHYT EMYEMLTLMS
     PPLGLGKRCP SKVAYKRLVL MNMPVAEDMT VHFTSTLMAL IRTALDIKIA KGGADRQQLD
     SELQKETLAI WPHLSQKMLD LLVPMPKASD LTVGKIYAAM MIMDYYKQSK VKKQRQQLEE
     QKNAPMFQRM EPSSLPQEII ANAKALPYLQ QEHVFSRSGR TGYPSMSPLS PQEIFQLACM
     DPADDGQFQE QQSLEPEVSE FKSVQPANHG IYLPSDTQEH AGSGRASSMP RLTVDPQVVT
     DPSSMRRSFS TIRDKRSNSS WLEEFSMERS SENTYKSRRR SYHSSLRLSA HRLNSDSGHK
     SDTHRSGGRE RGRSKERKHL LSPDVSRCNS EERGTQADWE SPERRQSRSP SEGRSQTPNQ
     QGTGSLSESS IPSVSDTSTP RRSRRQLPPV PPKPRPLLSY SSLIRHAGSI SPPADGSQEG
     SPLTSQALES NNACLTESSN SPHPQQGQHI SPQRYISEPY LAQHEDSHAS DCGEEETLTF
     EAAVATSLGR SNTIGSAPPL RHSWQMPNGH YRRRRRGGPG SGMMCGAVNN LLSDTEEDDK
     C
//
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