ID F7HUP0_CALJA Unreviewed; 332 AA.
AC F7HUP0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 4.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Pleckstrin homology domain containing B2 {ECO:0000313|Ensembl:ENSCJAP00000047140.4};
GN Name=PLEKHB2 {ECO:0000313|Ensembl:ENSCJAP00000047140.4};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000047140.4, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000047140.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000047140.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F7HUP0; -.
DR Ensembl; ENSCJAT00000053237.4; ENSCJAP00000047140.4; ENSCJAG00000011033.5.
DR eggNOG; ENOG502S9ZQ; Eukaryota.
DR GeneTree; ENSGT00390000013989; -.
DR HOGENOM; CLU_102020_0_0_1; -.
DR InParanoid; F7HUP0; -.
DR OMA; YIGSEVM; -.
DR TreeFam; TF331787; -.
DR Proteomes; UP000008225; Chromosome 6.
DR Bgee; ENSCJAG00000011033; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:Ensembl.
DR CDD; cd13265; PH_evt; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039680; PLEKHB1/2.
DR PANTHER; PTHR14309; EXPRESSED PROTEIN; 1.
DR PANTHER; PTHR14309:SF8; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY B MEMBER 2; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 311..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 99..206
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 27..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..65
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 332 AA; 36795 MW; DD374152C7968031 CRC64;
MTLRAPRLCC LPGAALPFAQ LRLARPASPQ TALPPTLRSH RSRQPHFRPS ALRRGRARHV
TAQRARSRGG PRDARMDEGG RARTWASLQG LPGACEEMAF VKSGWLLRQS TILKRWKKNW
FDLWSDGHLI YYDDQTRQNV EDKVHMPVDC INIRTGQECR DIQPPDGKSK DCMLQIVCRD
GKTISLCAES TDDCLAWKFT LQDSRTNTAY VGSAVMTDET SVVSSPPPYT AYAAPAPEAY
GYGPYGGAYP PGTQVVYAAN GQAYAVPYQY PYAETILMTR HCTAVSRGLY GQPPANQVII
RERYRDNDSD LALGMLAGAA TGMALGSLFW VF
//
