ID F7I1P6_CALJA Unreviewed; 624 AA.
AC F7I1P6;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Polycystin 2 like 2, transient receptor potential cation channel {ECO:0000313|Ensembl:ENSCJAP00000011391.4};
GN Name=PKD2L2 {ECO:0000313|Ensembl:ENSCJAP00000011391.4};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000011391.4, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000011391.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000011391.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
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DR AlphaFoldDB; F7I1P6; -.
DR STRING; 9483.ENSCJAP00000011391; -.
DR Ensembl; ENSCJAT00000012019.5; ENSCJAP00000011391.4; ENSCJAG00000006165.5.
DR GeneTree; ENSGT00940000161122; -.
DR InParanoid; F7I1P6; -.
DR OMA; VNTDMYY; -.
DR Proteomes; UP000008225; Chromosome 2.
DR Bgee; ENSCJAG00000006165; Expressed in heart and 2 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR003915; PKD_2.
DR InterPro; IPR046791; Polycystin_dom.
DR PANTHER; PTHR10877:SF47; POLYCYSTIC KIDNEY DISEASE 2-LIKE 2 PROTEIN; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR PRINTS; PR01433; POLYCYSTIN2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PIRSR:PIRSR603915-1};
KW Calcium channel {ECO:0000256|PIRSR:PIRSR603915-1};
KW Calcium transport {ECO:0000256|PIRSR:PIRSR603915-1};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|PIRSR:PIRSR603915-1};
KW Ion transport {ECO:0000256|PIRSR:PIRSR603915-1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR603915-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|PIRSR:PIRSR603915-1}.
FT TRANSMEM 32..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 318..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 469..490
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 77..272
FT /note="Polycystin"
FT /evidence="ECO:0000259|Pfam:PF20519"
FT DOMAIN 273..497
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
FT BINDING 583
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR603915-1"
FT BINDING 592
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR603915-1"
FT DISULFID 141..154
FT /evidence="ECO:0000256|PIRSR:PIRSR603915-2"
SQ SEQUENCE 624 AA; 74027 MW; 2ED6B549FAEA4ABF CRC64;
MAEASRWHRG GTSKHKLHYR NEVEIRTTLQ ELLLYFIFLI NLCILTFGMV NPHMYYLNKV
MSSLFLDTSV PGEERTNFKS IRSITEFWKF MEGPLLEGLY WDSWYNNQQL YNLKNSSRIY
YENILLGVPR VRQLKVRNNT CKVYSSFQSS ISECYGKYTS ANEDLSNFGL TSNSEWRYST
SNTNSPWHWG FLGVYRNGGY IFTLSKSKSE TKNKFIDLRL NNWITRGTRV IFIDFSLYNA
NVNLFCIIRL VAEFSATGGI ITSWQFYSVK LLRYVSYYDY FIASCEITFC IFLFVFTTQE
VKKIKEFKSN YFKSIWNWLE LLLLLLCFVA VSFNIYCNIQ IFLLLGQLLK STEKYSDFYF
LAYWHIYYNN IIAITIFFAW IKIFKFISFN KTMSQLSSTL SRCIKDIVGF AVMFFIIFFA
YAQLGFLVFG SQVDDFSTFQ NSIFAQFRIV LGDFNFAGIQ QANHILGPIY FITFIFFVFF
VLLNMFLAII NDTYSEVKAD YSIGRRPDFE LGKMIKQSYK NVLEKLRLKK AQKDEDKKTK
DSRDLAEQAR REGFDENEIQ KAEQMKKWKE RLEKKYYSEE IQDDYQPVTQ QEFQELFLYA
VELEKELHYI NLKLNQVMRK LSAL
//
