ID F7IL44_CALJA Unreviewed; 334 AA.
AC F7IL44;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 4.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Biliverdin reductase A {ECO:0000313|Ensembl:ENSCJAP00000014516.5};
GN Name=BLVRA {ECO:0000313|Ensembl:ENSCJAP00000014516.5};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000014516.5, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000014516.5}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000014516.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F7IL44; -.
DR STRING; 9483.ENSCJAP00000014516; -.
DR Ensembl; ENSCJAT00000015305.5; ENSCJAP00000014516.5; ENSCJAG00000007829.5.
DR eggNOG; ENOG502QTSZ; Eukaryota.
DR GeneTree; ENSGT00390000011072; -.
DR HOGENOM; CLU_053157_0_0_1; -.
DR InParanoid; F7IL44; -.
DR OMA; HEGHIRQ; -.
DR TreeFam; TF342889; -.
DR Proteomes; UP000008225; Chromosome 8.
DR Bgee; ENSCJAG00000007829; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004074; F:biliverdin reductase (NAD(P)+) activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0042167; P:heme catabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR017094; Biliverdin_Rdtase_A.
DR InterPro; IPR015249; Biliverdin_Rdtase_cat.
DR InterPro; IPR000683; Gfo/Idh/MocA-like_OxRdtase_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43377; BILIVERDIN REDUCTASE A; 1.
DR PANTHER; PTHR43377:SF1; BILIVERDIN REDUCTASE A; 1.
DR Pfam; PF09166; Biliv-reduc_cat; 1.
DR Pfam; PF01408; GFO_IDH_MocA; 1.
DR PIRSF; PIRSF037032; Biliverdin_reductase_A; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NADP {ECO:0000256|PIRSR:PIRSR037032-1};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT DOMAIN 47..163
FT /note="Gfo/Idh/MocA-like oxidoreductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01408"
FT DOMAIN 171..281
FT /note="Biliverdin reductase catalytic"
FT /evidence="ECO:0000259|Pfam:PF09166"
FT BINDING 54..57
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000256|PIRSR:PIRSR037032-1"
FT BINDING 82..84
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000256|PIRSR:PIRSR037032-1"
FT BINDING 115..118
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000256|PIRSR:PIRSR037032-1"
FT BINDING 136
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000256|PIRSR:PIRSR037032-1"
SQ SEQUENCE 334 AA; 37627 MW; F85B6BD0E12AEE12 CRC64;
MQIRGLPSTL GLLDQNLAAE PRNIHFQQES QLPKEETKMN TEPERKFGVV VVGVGRAGSV
RMRDLRNPHP SSAFLKLIGF VSRRELGSID GVQQISLEDA LSSQEVEVAY ICSESSSHED
YIRQFLNAGK HVLVEYPMTL SLVAAQALWE LAAQKGKVLH EEHVELLMEE FAFLKKEVVG
KDLLKGSLLF TAGPLEEERF GFPAFSGISR LTWLVSLFGE LSLVSATLEE RKEDQYMKMT
VCLETEKKSP LTWIEEKGPG LKRNRYLSFH FKSGSLENVP NVGINKNIFL KDQNIFVQKL
LGQFSEKELA AEKKRILHCL GLAEEIQKYC CSGK
//
