ID F7ILP4_CALJA Unreviewed; 1085 AA.
AC F7ILP4; U3BWL4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 2.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=LATS2 {ECO:0000313|EMBL:JAB10877.1,
GN ECO:0000313|Ensembl:ENSCJAP00000043996.2};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000043996.2, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000043996.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB10877.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Bladder {ECO:0000313|EMBL:JAB10877.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
RN [3] {ECO:0000313|Ensembl:ENSCJAP00000043996.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; GAMT01000984; JAB10877.1; -; mRNA.
DR STRING; 9483.ENSCJAP00000043996; -.
DR Ensembl; ENSCJAT00000063445.4; ENSCJAP00000043996.2; ENSCJAG00000005013.5.
DR eggNOG; KOG0608; Eukaryota.
DR GeneTree; ENSGT00940000159161; -.
DR HOGENOM; CLU_004885_1_0_1; -.
DR OMA; FNNHQQP; -.
DR TreeFam; TF351549; -.
DR Proteomes; UP000008225; Chromosome 5.
DR Bgee; ENSCJAG00000005013; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0035329; P:hippo signaling; IEA:Ensembl.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0001827; P:inner cell mass cell fate commitment; IEA:Ensembl.
DR GO; GO:0001828; P:inner cell mass cellular morphogenesis; IEA:Ensembl.
DR GO; GO:0030216; P:keratinocyte differentiation; IEA:Ensembl.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:1900181; P:negative regulation of protein localization to nucleus; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0008104; P:protein localization; IEA:Ensembl.
DR GO; GO:0046620; P:regulation of organ growth; IEA:Ensembl.
DR GO; GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR CDD; cd21777; MobB_LATS2; 1.
DR CDD; cd05626; STKc_LATS2; 1.
DR CDD; cd14398; UBA_LATS2; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR000961; AGC-kinase_C.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR017892; Pkinase_C.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR24356; SERINE/THREONINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR24356:SF149; SERINE_THREONINE-PROTEIN KINASE LATS2; 1.
DR Pfam; PF00069; Pkinase; 2.
DR Pfam; PF00433; Pkinase_C; 1.
DR SMART; SM00133; S_TK_X; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS51285; AGC_KINASE_CTER; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS50030; UBA; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:JAB10877.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 98..139
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 665..970
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 971..1049
FT /note="AGC-kinase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51285"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 537..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1053..1085
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 548..568
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1058..1077
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 694
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1085 AA; 120290 MW; 0EF66CA16C565D6D CRC64;
MRPKTFPATT YSGNSRQRLQ EIREGLKQPS KSSAQGLSVG PNSDTSLDTK ILGSKDATRQ
QQQMRATPKF GPYQKALREI RYSLLPFANE SGTSAAAEVN RQMLQELVNA GCDQEMAGRA
LKQTGSRSIE AALEYISKMG YLDPRNEQIV RVIKQTSPGK GLMPTPVTRR PSFEGTRDSF
ASYHQLSGGA PYEGPSFGAD GPAALEEVPR PYVDYLFPGV GPHGPGHQHQ HQHPPKGYGA
SVEAAGAHFP LQGAHYGRPH LLVPAEPLGY GVQRSPSFQS KTPPETGGYA SLPAKAQGGP
PGTSLAFPPP TSGIYVTHPH HKQASPAAHQ LHLLGSRSQV FTSDSPPQSL LTPSRNSLNV
DLYELGSTPV QQWPAATLAR RDSLQKPGLE APPRAHGTFR PDCPVPSRTN SFNSHQPRSG
APGKAEPSLP ASNTVTAVTA AHILHPVKSV RVLRPEPQTA VGPSHPAWVP APVPAPAPEG
LDAKEEHALT LGGAGAYPLD MEYGGPDRRC PPPPYPKHLL LRSKSEQYDL DSLCAGVEQS
LRGGPSEPDG GDKSRKSTKA DKGGKDKKQI QTSPVPVRKN SRDEEKRESR IKSYSPYAFK
FFMEQHVENV IKTYQQKVNR RLQLEQEMAK AGLCEAEQEQ MRKILYQKES NYNRLKRAKM
DKSMFVKIKT LGIGAFGEVC LACKVDTHAL YAMKTLRKKD VLNRNQVAHV KAERDILAEA
DNEWVVKLYY SFQDKDSLYF VMDYIPGGDM MSLLIRMEVF PEHLARFYIA ELTLAIESVH
KMGFIHRDIK PDNILIDLDG HIKLTDFGLC TGFRWTHNSK YYQKGNHVRQ DSMEPSDLWD
DVSNCRCGDR LKTLEQRARK QHQRCLAHSL VGTPNYIAPE VLLRKGYTQL CDWWSVGVIL
FEMLVGQPPF LAPTPTETQL KVINWENTLH IPAQVKLSPE ARDLITKLCC AADHRLGRNG
ADDLKAHPFF STIDFSSDIR KQPAPYVPTI SHPMDTSNFD PVDEESPWND ASEGSAKAWD
TLTSPSNKHP EHAFYEFTFR RFFDDNGYPF RCPKPSGAEA SQSENSNLET SDLMDQTEGC
QPVYV
//
